Furthermore, since FSH induction of aromatase activity can be blocked by a tyrosine kinase inhibitor without affecting the level of cAMP production, it can be suggested that tyrosine kinase(s) act downstream of cAMP production and protein kinase A activation....
Estrogen therapy in women over 60 years of agedoi:10.3109/09513599409072454EstrogenTherapyHRTKey Words: Estrogen Therapy, HRTJ.ChelseaStuddChelseaD.ChelseaZambleraChelseaInformaworldGynecological Endocrinology
We reveal that the colon transcriptome, which responded to HFD-feeding in a sex-dependent manner, were particularly enriched for pathways involved in cell proliferation. HFD clearly increased and E2 treatment opposed the HFD-induced proliferation, both at the transcriptome and functional (Ki67) level...
Transcriptional changes have the potential to alter both cellular physiology and circuit-level signaling, which may have region-specific effects. For example, while activity in the ventral hippocampus to NAc projections promotes susceptibility, activity in prefrontal cortex (PFC) to NAc projections promote...
3, prevention of osteoporosis: women with decreased level of estrogen secretion,prevent bone calcium stripping function is abate, cause bone loss, osteoporosis. 4, the prevention of cardiovascular disease: soybean isoflavone can effectively reduce the concentration of low density lipoprotein in blood, in...
[70]. In addition, the chemotherapeutic treatments of esophageal squamous cell promote the phosphorylation of ERK, consequently enhancing the expression level of PD-L1 and responding for tumor metastasis [71]. As the agonist of ERK, the stimulation of E2may promote the expression level of PD-L1...
Women with a first diagnosis of invasive breast cancer between 1993 and 1996 were identified by the North Carolina Central Cancer Registry through a rapid case ascertainment system. Women diagnosed before the age of 50 years and African American women were oversampled to ensure that they comprised ...
Serum estrogen level, attention, memory and other cognitive functions in middle-aged women. Climacteric 1999; 2:115–23. CrossRef Barrett-Connor E, Goodman-Gruen D. Cognitive function and endogenous sex hormones in older women. J Am Geriatr Soc 1999; 47:1289–93. Drake EB, Henderson VW, ...
The skeleton is also an estrogen-responsive organ, and the importance of estrogen for the skeleton in women is well established4. In recent decades, the importance of estrogen for male skeletal health has been increasingly recognized. Human and rodent studies have shown that estrogen is involved ...
Interestingly, there was no sex difference in the level of DHEA, the precursor of these steroids. Levels of 7α-OH-DHEA, a metabolite of DHEA with a weak affinity for ERβ, also did not differ between sexes. Both men and women with depression in this study were taking anti- ...