they are converted to estrogens through the action of anenzymeknown asaromatase. The ovaries are the richest source of aromatase, although some aromatase is present inadipose tissue, which is also an important source of estrogen in postmenopausal women.Estradiol, the most potent estrogen, is synthes...
alsooes·tro·gen(ĕs′trə-jən) n. 1.Any of several steroid hormones, such as estradiol and estrone, that are produced primarily by the ovaries, stimulate the development and maintenance of female secondary sex characteristics, exert systemic effects such as the growth and maturation of...
The meaning of ESTROGEN is any of various natural steroids (such as estradiol) that are formed from androgen precursors, that are secreted chiefly by the ovaries, placenta, adipose tissue, and testes, and that stimulate the development of female secondar
Like SKOV-3ip, the increased integrin expression on OV3 cells exposed to estradiol, and enhanced gene transduction mediated by A520/ N584RGD–rAAV2–GFP was also observed, as shown in Figure 5. This is in accordance with a previous study on the wt-rAAV2-reduced gene expression in female ...
Estrogen is known to retard the development of atherosclerosis and to work in the brain, but the mechanism of hormonal action is completely unknown. We inv... T Hayashi,T Ishikawa,K Yamada,... - 《Biochemical & Biophysical Research Communications》 被引量: 153发表: 1994年 Immunoglobulin free...
In vitro experiments also show that estrogen may have a direct impact on B and T cells by inducing rapid signaling events, such as Erk and AKT phosphorylation, cell-specific Ca2+ signal, and NFκB activation. These non-transcriptional effects are mediated by classical estrogen receptors and ...
Historically, a high level of estrogen in women is regarded as the signature for a longer lifespan than men. Estrogen is known to be responsible for the development and regulation of the female reproductive system and secondary sex characteristics. Ovariectomy brings on numerous complications such as...
(WHI) also failed to substantiate a significant role for HT in enhancing mood[21]. It must be noted, however, that these trials studied estrogen combined with aprogestin, which may have countered any antidepressant effect of the estrogen. It is not known if ET alone yields similar results, ...
Brown adipose tissue (BAT) specializes in the regulated production of heat, also known as “adaptive” or “non-shivering” thermogenesis (Cannon and Nedergaard, 2004). To fulfill this function, BAT is rich in mitochondria and expresses the mitochondrial uncoupling protein 1 (Ucp1). Upon exposure...
(VMH, also known as VMN), the arcuate nucleus (ARH), the paraventricular nucleus of the hypothalamus (PVH), the nucleus of solitary tract (NTS), and the medial amygdala2,3,4,5. In particular, the VMH has been well-documented in the regulation of glucose balance6. Many VMH neurons are...