the free hormone penetrates thecellsurface and then binds to a protein known as an estrogenreceptorin thecytoplasmof the cells. The estrogen-receptor complexes enter the cellnucleus, where they modulateprotein synthesisby influencing the rate at which particulargenesaretranscribed. Gene transcription is...
The article focuses on a study presented at the Endocrine Society's annual meeting in Toronto, Ontario, which reveals the link between serum estradiol, testosterone, and sex hormone-binding globulin and bone mineral density level in men. Coinvestigator Doctor Adrian Dobs, says it looks like ...
A. Hormone-PAMAM dendrimer conjugates: polymer dynamics and tether structure affect ligand access to receptors. Angew. Chem. Int. Ed. Engl. 45, 7243–7248 (2006). Article CAS PubMed Google Scholar Chambliss, K. L. et al. Non-nuclear estrogen receptor alpha signaling promotes cardiovascular ...
1 Schizophrenia (SCZ) is a neuropsychiatric disorder which displays sex differences in its clinical manifestations, including women presenting with later age at onset, less severe course, and better response to antipsychotics in comparison with men. Estrogen is a steroid hormone which, in addition to...
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Although the mechanisms underlying gender-related differences in body fat distribution and lipid homeostasis remain to be fully determined, the reported differences appear to principally reflect the actions of the sex steroid hormone estrogen on whole-body lipid metabolism. In the present review, we ...
Experimental data and the presence of sex hormone receptors suggest an important role of sex steroids in the regulation of the function of TMN neurons. Therefore, we investigated sex-, age- and Alzheimer-related changes in estrogen receptor α and β (ERα and ERβ) in the TMN. In addition...
The reactions of four anti-sex hormone (Estrone, Estradiol, Estriol and Testosterone) antisera were immunohistochemically examined in 109 cancerous and 80 normal and benign thyroid tissues. Four kinds of sex hormones were detected in the tumour cells of 61 cases (56%) of thyroid cancer and in...
Furthermore, pharmacological inhibition of the aromatase activity resulted in the anticipated normalization of the hormone levels (Fig. 1A). Thus, the male AROM+ mice were confirmed to be suitable for studying E/A on the humoral immune response. Next, plasma immunoglobulin levels were measured, ...