Taken together, estrogen could be beneficial to intrinsic aging but potentially harmful to photoaging in the skin. It is important to keep in mind the fact that estrogens might have differential effects on the skin in the presence of UV irradiation....
the effect of testosterone on the skinis to “masculinize” the texture and quality of the skin, while the effect of estrogen throughout the reproductive years of the female is to “feminize” the skin and other tissues. These effects would impart...
Thus, differential tissue-specific ER-mediated effects on skin healing reveal important new targets for future therapies to promote effective healing. Materials and Methods Animal experiments All animal studies were approved by the UK Government Home Office (Project License 40/3203). C57BL/6 mice ...
Interestingly, there are also naturally occurring steroids in the body that are also a type of hormone. Based on the body’s receptors, they have been classified into five groups: glucocorticoids, mineralocorticoids, androgens, oestrogens, and progestogens. In the form of corticosteroids, are a ...
Thus, the beneficial effects of estrogen on skin wound healing are mediated by epidermal ERbeta, in marked contrast to most other tissues in the body where ERalpha is predominant. Surprisingly, agonists to both ERalpha and ERbeta are potently antiinflammatory during skin repair, indicating clear ...
Estrogens tend to decrease serum cholesterol concentrations and to increase serumtriglycerideconcentrations. The overall effect of these changes, perhaps in conjunction with direct effects of estrogens onblood vessels, is to protect againstatherosclerosisbeforemenopause. Estrogens also increase the serum concent...
The Effects of Estrogen Estrogen is a sex hormone that affects many systems in the body, including the reproductive system, bones, skin, and brain. Beginning at puberty, a woman's ovaries start releasing estrogen in coordination with each monthlymenstrual cycle. At mid-cycle, levels suddenly spi...
Estrogen deficiency, for example in postmenopausal women, is detrimental to wound healing processes, notably inflammation and re-granulation, while exogenous estrogen treatment may reverse these effects. Understanding the role of estrogen on skin might provide further opportunities to develop estrogen-...
If your body produces too much testosterone, you may have irregular or absent periods. You may also have more body and facial hair than the average woman. Some women with hightestosteronelevels develop frontal balding. Other possible effects include acne, an enlarged clitoris, increased muscle mass...
It has also been shown that hormone replacement therapy as well as therapy using SERM can have a positive effect on skin aging [95], [96], [97]. Several other studies have linked the loss of ELC with the prolapse of pelvic organs [98], [99], a process highly associated with the ...