Estrogen is one of the two main sex hormones in women and is synthesized mainly in the ovaries and comes in three forms in the body: estrone (E1), estradiol (E2), and estriol (E3). Estradiol predominates between menarche and menopause and can be converted to testosterone via the enzyme ar...
In males, testosterone is converted to estrogen and maintains fuel homeostasis via ERs and AR, which share related functions to suppress adipose tissue accumulation and improve insulin sensitivity. We suggest that ERs and AR could be potential targets in the prevention of age-related metabolic ...
moderate androgenic activity. This compound crosses thebasal membraneinto the surrounding granulosa cells, where it is converted to estrone or estradiol, either immediately or through testosterone. The conversion of testosterone to estradiol, and of androstenedione to estrone, is catalyzed by the enzyme...
Despite the controversy and warnings, the Age of estrogen had well and truly begun. Over the following decades, DES and other exogenous estrogens were marketed and prescribed for a bewildering, often contradictory, range of conditions: to slow and prevent aging; to stop hot flushes and as treatm...
(E3), as shown inFig. 12.1. Small amounts of androstenedione are secreted or converted to testosterone, but most androstenedione returns to the granulosa cells where it is converted to estrone, and then to estradiol under the influence of follicle-stimulating hormone (FSH).5Estrone (E1) is ...
Testosterone, a male sex hormone, is known to suppress the immune system. Conversely, estrogen and other hormones in the same family push the immune system to produce and react to antibodies, leading to immune responses. People with lupusmay be more sensitive to the estrogen in their bodiesdue...
crosses the basal membrane to reach the granulosa cells where it will be converted either into estrogen (particularly, into estrone andestradiol) or intotestosterone. The testosterone can later be converted into estradiol by another enzymatic step using aromatase, an enzyme in granulosa cells that cat...
Anastrozole (Table1), functioning as an aromatase inhibitor, effectively prevents the conversion of testosterone into E2, leading to reduced E2 levels [179]. In preclinical studies, administration of anastrozole significantly mitigated pulmonary vascular remodeling, decreased right ventricular systolic pressure...
Sex- and Age-Related Response to Aromatase Deficiency in Bone Deficiency of sex steroids causes osteoporosis, but the relationship between estrogen and androgen is not clear because androgen is converted into estrogen... Chisato,Miyaura,and,... - 《Biochemical & Biophysical Research Communications》 ...
Testosterone as well as estrogen increases serotonin2A receptor mRNA and binding site densities in the male rat brain. DHT, a potent androgen which cannot be converted to estrogen, suggests that the action of testosterone depends upon its conversion to estrogen by aromatase... BEH Sumner,G Fink ...