Estrogen causes breat cancer: increasing duration of use of postmenopausal hormones increases risk of breast cancerEscherichia-coliTrichoderma-reeseiCaldocellum-saccharolyticumBeta-1,4-mannanase geneAlkalophilic bacillusMolecular-cloningActive-siteKraft pulp...
In accordance with this finding, the sensitivity to tamoxifen treatment of estrogen and HER4 receptor-positive ZR-75-1 breast cancer cells can be significantly enhanced by HER4 knockdown. Conclusion We suggest an HER4/estrogen receptor interaction that impedes tamoxifen binding to the estrogen ...
Breast cancer is a major health burden in female around the world, which causes the most frequent women cancer prevalence and results in the second leading cause of cancer-related death in women worldwide [1]. Breast cancer has been divided into at least three subtypes (Luminal, HER2-enriched...
Objective: We studied the risk of breast and endometrial cancer in a cohort of 11,231 Swedish women prescribed different replacement hormone regimens. Meth... I Persson,E Weiderpass,L Bergkvist,... - 《Cancer Causes & Control Ccc》 被引量: 561发表: 1999年 Breast Cancer after Use of Estro...
This study examines the relationship between menopausal estrogen and estrogen-progestin replacement therapy and risk of breast cancer, focusing on whether ... C Schairer,C Byrne,PM Keyl,... - 《Cancer Causes & Control》 被引量: 0发表: 1994年 Past use of hormone therapy and breast cancer ris...
Worldwide, breast cancer has become the second most common cancer in women. The disease has currently been named the most deadly cancer in women but little is known on what causes the disease. We present the effects of estrogen as a risk factor on the dynamics of breast cancer. We develop...
We found that breast cancer causing,17 -estradiol (E2)-bound estrogen receptor (ER ) on enhancers causes a global upregulation of eRNA transcription in enhancers adjacent to E2 upregulated coding genes in MCF-7 (Breast cancer cells). These induced eRNAs are required for the observed induction ...
Gastric cancer is one of the most common types of cancer and one of the leading causes of cancer-related deaths worldwide, with an estimated 723100 deaths and 951600 new cases in 2012[1]. Currently, tremendous efforts are being made to investigate the cellular and molecular mechanisms leading ...
Tetsu O, McCormick F (2003) Proliferation of cancer cells despite CDK2 inhibition. Cancer Cell 3: 233–245 Article CAS Google Scholar Varma H, Skildum AJ, Conrad SE (2007) Functional ablation of pRb activates Cdk2 and causes antiestrogen resistance in human breast cancer cells. PLoS One ...
Although paradoxical because estrogen is recognized to stimulate breast cancer growth, laboratory data support a mechanism of estrogen-induced apoptosis under the correct environmental circumstances. Long-term antiestrogen treatment or estrogen deprivation causes the eventual development and evolution of anti...