Testosterone is a male sex hormone (androgen) that is mainly produced in men’s testicles. The testicles primarily make testosterone in men. Women’s ovaries also produce testosterone, though in much smaller amounts. Testosterone plays an essential role in men’s health. It is responsible for m...
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As shown in Figure 9-5, either IL-1 or TNF-α blockade reduced the estrogen-deficiency-induced increase in bone resorption by ~50%, although TNF-α blockade appeared to be more effective (due to potential toxicity, both blockers could not be administered simultaneously). Sign in to download...
Identification of sex-based immunoregulatory differences and mechanisms of hormonal immunomodulation would be of potential benefit to both women and men as it would provide a better understanding of immunity and probable autoimmune disease pathogenesis as well as a basis for incisive in vivo investigations...
Not only is estrogen produced internally, it’s also produced in reaction to chemicals and other substances in our food. When it is not broken down adequately, higher levels of estrogen build up. This is true for both men and women, although the effects are more easily recognized in men. ...
Addition of nifedipine (1μM, L-type calcium channel blocker) resulted in a ~40% decrease in [Ca 2+ ] i compared to control. This nifedipine blunting effect was similar in PPT treated group and to a higher extend to the WAY on [Ca 2+ ] i responses to histamine, suggesting that ER...
The role of androgens was studied in 15 eugonadal male subjects (who presented for female role reassignment) by determining the effects of a novel nonsteroidal androgen receptor blocker, Anandron, on basal and LH-releasing hormone (LHRH)-stimulated serum LH/FSH levels; LH pulse frequency and ...