However, its role in thyroid cancer stem cell maintenance remains elusive. Here, we report that ERβ is overexpressed in papillary thyroid cancer stem cells ... M Li,HF Chai,F Peng,... - 《Cell Death & Disease》 被引量: 0发表: 2018年 Estrogen and its receptors in the growth ...
The expression of ERs in thyroid cancer tissues and different pathological types were analyzed using the χ~2 test. Results The number of cases with positive expression of ER in thyroid cancer tissues was 36. The number of papillary thyroid cancers(PTCs) was 48, with positive expression of ERs...
However, its role in thyroid cancer stem cell maintenance remains elusive. Here, we report that ERβ is overexpressed in papillary thyroid cancer stem cells (PTCSCs), whereas ablation of ERβ decreases stemness-related factors expression, diminishes ALDH cell populations, and suppresses sphere ...
In this Review, we summarize this evidence and discuss its implications for understanding the regulation of trabecular and cortical bone mass; the integration of hormonal and mechanical signals; the relative importance of estrogens versus androgens in the male skeleton; and, finally, the pathogenesis ...
The reactions of four anti-sex hormone (Estrone, Estradiol, Estriol and Testosterone) antisera were immunohistochemically examined in 109 cancerous and 80 normal and benign thyroid tissues. Four kinds of sex hormones were detected in the tumour cells of 61 cases (56%) of thyroid cancer and in...
support its functional role as a mER for 17β-estradiol. However, another laboratory has reported thatERKactivation andcAMPaccumulation in response to 17β-estradiol is abrogated in ERα−/GPR30+SKBR3 cells. This may be due to differences in the parameters (fluorescence localization versus...
Estrogen, any of a group of hormones that primarily influence the female reproductive tract in its development, maturation, and function. There are three major hormones—estradiol, estrone, and estriol—among the estrogens, and estradiol is the predomina
Managing Aromatase Inhibitors in Breast Cancer Survivors: Not Just for Oncologists The role of the general internist in the care of breast cancer survivors is increasing as the number of women living with breast cancer continues to rise. ... Julia A Files, Marcia G Ko, Sandhya Pruthi - 《Ma...
This study aimed to enhance the understanding of the role of estrogen in lymphangioleiomyomatosis(LAM) and to conclude the impact of estrogen-altering events on the condition and recent advances in estrogen-based treatments for LAM. Results LAM development is strongly linked to mutations in the tub...
By employing these methods, more precise understanding of specific gene expression and evaluation of its biological significance in the ovary would be possible. 展开 关键词: estrogen receptor α estrogen receptor β immunohistochemistry in situ hybridization southwestern histochemistry mouse ovary ...