Postmenopausal women are at high risk of disease, such as coronary heart disease, stroke, malignancies, dementia and osteoporosis. This is due to decreased levels of estrogen/estradiol, produced mainly in the ovaries, leading to reduced bone mineral density (BMD), which is the gold standard for...
It has been found recently that women with estradiol (E) levels < 5 pg/ml were more likely to suffer osteoporotic fractures. We evaluated the relationships between biomarkers of bone turnover and changes in hormone levels in early or late postmenopausal women without any replacement therapy. Folli...
This hormone plays a crucial role in the development of female sex characteristics—like breasts—and in regulating the menstrual cycle and reproduction. Optimal estradiol levels in postmenopausal women are associated with a reduced likelihood of age-related conditions like bone mineral density decline ...
If these results wind up being replicated in a large sample of postmenopausal women not at risk for dementia, estradiol-based hormone therapy could become more broadly a treatment of choice to preserve optimal brain aging, she said.
The effects of ethanol on the clearance of estradiol in postmenopausal women Objective To determine whether acute alcohol ingestion affects the pattern of decline of circulating E2 levels after removal of transdermal E2 patches. Des... Elizabeth,S.,Ginsburg,... - 《Fertility & Sterility》 被引量...
Quality of life of postmenopausal women on a regimen of transdermal estradiol therapy: a double-blind placebo-controlled study. Am J Obstet Gynecol. 1993;168:824–30. Article CAS PubMed Google Scholar Formby B, Schmidt F. Efficacy of biorhythmic transdermal combined hormone treatment in ...
Effects of administration of 17β‐oestradiol on serum leptin levels in healthy postmenopausal women OBJECTIVEWomen have higher leptin levels than men at a certain degree of adiposity. The role of oestrogens in the regulation of serum leptin levels remains... JMH Elbers,Gerdien W. de Valk De Roo...
Effect of transdermal hormone replacement therapy on carotid artery wall thickness and levels of vascular inflammatory markers in postmenopausal women. Hypertens Res. 2005;28:579–84. Article CAS PubMed Google Scholar Edwards DP. Regulation of signal transduction pathways by estrogen and progesterone. ...
delivers estradiol (the major estrogen in premenopausal women) into the systemic circulation at a constant rate for up to 4 days. Because this method of delivery avoids first-pass hepatic metabolism, premenopausal levels of estradiol can be maintained in postmenopausal women using very low dosages....
Women with both higher E2 and hs-CRP (defined as values into the upper tertile) had an age-adjusted OR of 4.2 (95% CI, 1.7-10.5; P = 0.002), compared with women with low levels of both E2 and hs-CRP. CONCLUSION: Higher E2 levels were associated with frailty in postmenopausal women...