Compared to other commonly used estradiol esters, via the intramuscular route, Estradiol cypionate is found to have the longest duration of action with a duration of ~11 days, 分子量 396.56 Formula C26H36O3 CAS 号 313-06-4 运输条件 Room temperature in continental US; may vary ...
The use of unopposed estrogens in women with intact uteri has been associated with an increased risk of endometrial cancer. The reported endometrial cancer risk among unopposed estrogen users was about 2-to-12-fold greater than in non-users, and appears dependent on duration of treatment and on ...
However, the duration of lordosis was markedly attenuated in comparison to the duration shown by intact cycling females. This study was designed to examine whether dual implantation of E 2 in the diencephalon would facilitate patterns of precopulatory and copulatory behaviors similar to those shown ...
In order to prolong the duration of action subcutaneous implants of estradiol may be used. The dose of estradi- ol is generally 25 to 100 mg with a new implant being given after about 4 to 8 months according to oestrogen concentrations. Estradiol 2099 Estradiol may be used locally either ...
When dissolved in oil and injected, esters of estradiol are well absorbed. The aryl and alkyl esters of estradiol become less polar as the size of the substitutes increases; therefore, the rate of absorption of oily preparations is progressively slowed and the duration of action can be prolonged...
Duration: Estradiol valerate, 7-8 days; estradiol cypionate, 11 days Distribution Widely distributed Protein bound: To globulin and albumin Elimination Half-life: 1.5-5 hr (IM); 4 hr (transdermal) Excretion: Mainly in urine (as conjugates with small amount of unchanged drug); most estrogens ar...
IM Injection: When conjugated with aryl and alkyl groups for parenteral administration, the rate of absorption of oily preparations is slowed with a prolonged duration of action, such that a single intramuscular injection of estradiol valerate or estradiol cypionate is absorbed over several weeks. Nata...
The results provide further evidence that estrogen metabolism occurs in estrogen-stimulated uteri and that it may be part of an adaptive response to limit the duration of action of this hormone upon its target tissue. 展开 关键词: Uterus Animals Rats Hydrogen Peroxide Carbon Radioisotopes Estradiol ...
To minimize risk of adverse effects, use the lowest possible effective dosage. Because of the potential increased risk of cardiovascular events, breast cancer, and venous thromboembolic events, limit estrogen and estrogen/progestin therapy to the lowest effective doses and shortest duration of therapy ...
Goy RW, Phoenix CH, Young WC (1966) Inhibitory action of the corpus luteum on the hormonal induction of estrous behavior in the guinea pig. Gen Comp Endocrinol 6:267–275 Hansen S, Sodersten P (1978) Effects of subcutaneous implants of progesterone on the induction and duration of sexual...