(VLDL,IDLand LDL). Under normal conditions, CETP-mediatedcholesteryl estertransfer from HDL is predominantly to LDL. When the plasma concentration ofVLDLis increased, as intype 2 diabetes, CETP-mediated cholesteryl ester transfer is preferentially directed towards the large VLDL particles, which ...
Sakai K, Igarashi M, Yamamuro D, Ohshiro T, Nagashima S, Takahashi M, et al. Critical role of neutral cholesteryl ester hydrolase 1 in cholesteryl ester hydrolysis in murine macrophages. J Lipid Res. 2014;55(10):2033-40.Sakai K, Igarashi M, Yamamuro D, et al. Critical role of neutral...
Chemoselective enzymatic hydrolysis of aliphatic and alicyclic nitriles Mild and selective hydrolysis of aliphatic and alicyclic nitriles leading to carboxylic acids and amides was achieved under neutral conditions by an immobi... AD Raadt,N Klempier,K Faber,... - 《Journal of the Chemical Socie...
Tetrazole 4 (alpha-isomer) showed 4-5-fold superior reactivity over 6 (beta-isomer) under identical conditions. Natural charges obtained from NBO analysis (B3LYP/6-31+G*) are -0.94 and -0.852 on N- in the conjugate bases of 4 and 6, respectively. This also predicts that 4 is a ...
For this reason, hydrolysis occurs and an ester and an amide are formed along with the release of an alcohol. It is generally done under the influence of some catalyst that may be either an acid or a base total depending on the situation. The reaction can be illustrated in the following ...
The large-scale use of organophosphate esters (OPEs) as flame retardants and plasticizers has led to their prevalence in the environment, with still unknown broader impacts. This Review describes the transport and occurrence of OPEs in marine systems and
They are prone to hydrolysis under moisture, pH, and even on-column stationary phases under neutral conditions. At the same time, boronate esters are considered as potential genotoxic substances; hence, their estimation is very important from the patient safety perspective. There are inherent ...
Respective hydrolysis and esterification of esterified and free plant stanols occur rapidly in human intestine after their duodenal infusion in triacyl- or diacylglycerol. Lipids. 2007;42:603–12. Article PubMed CAS Google Scholar Gylling H, Öörni K, Nylund L, Wester I, Simonen P. ...
(Miller et al., 1981). While the relative rates of hydrolysis for methylacrylate5,ethyl acrylate6, andbutyl acrylate7in tissue homogenates were similar, the hydrolysis rate in the liver homogenate was approximately 20 times faster than in the kidney and lung homogenates (Miller et al...
These results confirm that SN38 can be released from NK012 under neutral conditions, without the need of hydrolytic enzymes. In addition, less than 5% of SN38 was released in 5% glucose solution, suggesting that NK012 is stable until administered to physiological conditions. Recruitment for Phase ...