C1 structure as a “safe house” to protect mechanical rupture of disulfide bonds Inspired by the molecular mechanism that allows the integration of labile ester bond and weak protein fold to achieve remarkable mechanical stability, we hypothesized that it is also possible to use the C1 structure ...
How an optimal level of human dopamine D4 receptor (hD4R) is maintained in synaptic membranes is not known. We show here that hD4R is ubiquitinated in primary neurons. We go on to show that ubiquitin is attached to hD4R through isopeptide and ester bonds. When lysine (Lys) residues ...
Aconitinealkaloids with diester bonds appear to have the most toxicity compared with those alkaloids with no ester side chain, which have few clinical effects.11 View chapter Book 2007,Haddad and Winchester's Clinical Management of Poisoning and Drug Overdose (Fourth Edition) ...
(http://www.cazy.org) is a database that contains enzymes involved in the degradation, modification, or creation of glycosidic bonds (Cantarel et al.2009). One class of activities in this database is the carbohydrate esterases (CE). These enzymes remove ester-based modifications from ...
Thus one of these signals must have been due to the orthoester carbon (four bonds from H2-18) and the other due to acetal carbon C-5 (three bonds from H2-18). This confirmed the ring-closure of the (C-6)–(C-5)–(C-4)–(C-18)–(O) tetrahydrofuran. C-4 (δ 87.1), C-...
It has been shown that the critical factor for obtaining high stereoselectivity is a thermodynamic preference in the lithio derivative (9) and not a diastereoselective deprotonation. In essence, CLi bonds to sulfur are similar to their oxygen and nitrogen counterparts and differ only in the fact ...
after ethanol ingestion are commonly lost during extraction. As with fatty acids, FAEE moieties which contain two or more double bonds can be oxidized within minutes on a dried TLC plate and are thereby lost prior to quantification. To enhance the recovery of the relatively small amounts of ...
However, when alkali is used to neutralize the trifluoroacetic acid after removal of the BOC protecting group, the ester bonds of ARG and ARG-V are also easily ruptured. This method also difficult to operate and costly. Hydrochloric acid, a mineral acid, was later adopted, and the carbonyl ...
It is particularly important that, once structural protein has been removed, the chitinous material be sparsely esterified to restabilize it by forming sparse preferably inorganic ester bonds. Thus, once native chitin has been deproteinized (i.e., removing structural protein by a technique such as...
The term “alkyl” is specifically intended to include groups having any degree of level of saturation, e.g., groups having exclusively single carbon-carbon bonds, groups having one or more double carbon bonds, groups having mixtures of single, double, and triple carbon-carbon bonds. Where ...