S-Adenosylmethionine revisited: its essential role in the regulation of liver function. Alcohol. 2002; 27 :163–167.Avila MAG-TE, Martinez-Chantar ML, Latasa MU, Perez-Mato I, Martinez-Cruz LA, del Pino MM, Corrales FJ, Mato JM: S-Adenosylmethionine revisited: its essential role in the ...
NF-κB addiction and its role in cancer: 'one size does not fit all'. Activation of nuclear factor (NF)-κB, one of the most investigated transcription factors, has been found to control multiple cellular processes in cancer including inflammation, transformation, proliferation, angiogenesis, invas...
However, the precise role of PIK3C3 in mammals is not clear. Using mouse strains that allow tissue-specific deletion of PIK3C3, we have described an essential role of PIK3C3 in regulating autophagy, and liver and heart function.关键词: autophagy cancer endocytosis heart liver PIK3C3 PtdIns...
Here, we have demonstrated an essential role for the transcription factor GATA-3, a previously recognized Th2 cell master regulator, in controlling Treg cell function. Treg cell-specific GATA-3 deletion led to a spontaneous inflammatory disorder in mice. GATA-3-null Treg cells were defective in...
Consequently, the exogenous expression of Ahed restored blood cell production from Ahedm/m mutant ESCs to the WT level (Fig. 1f–h). These results indicate that the Ahed gene plays a non-redundant role in haematopoiesis after the Flk-1+ early mesodermal cell differentiation. Ahed gene product...
Hepatocytes exhibit different morphology depending on the surface condition of a cultural substratum. The growth response to mitogen and the expression of liver functions were also dependent on the cell morphology regulated by cell-cell interaction. In the present study, we examined the effects of tre...
An increasing number of studies indicate that adrenergic signalling plays a fundamental role in chronic stress-induced tumour progression and metastasis. However, its function in gastric cancer (GC) and its potential mechanisms remain unknown. The expres
Genes whose functions are essential in early ontogeny often play critical roles in later life. This is particularly true for genes involved in the haematopoietic system in mammals, in which diverse genes play delicate and coordinated roles in a time-dependent manner. Mutations in development-related...
In mammals, core TAFs are almost ubiquitously expressed, although cell-specifically expressed paralogues of TBP and a subset of TAFs have been described and their functions defined by mouse knockouts. Taf7l plays a critical role in male germ cell development and in adipocytes4–6, Taf4b is ...
Antifibrogenic role of the cannabinoid receptor CB2 in the liver. Methods: CB2 receptors were characterized in biopsy specimens of normal human liver and active cirrhosis by immunohistochemistry, and in cultures of hepatic ... B Julien,P Grenard,F Teixeira-Clerc,... - 《Gastroenterology》 被引量...