Method: In this paper, we propose a new method for predicting essential proteins in a protein interaction network, local interaction density combined with protein complexes (LIDC), based on statistical analyses of essential proteins and protein complexes. First, we introduce a new local topological ...
Moreover, a mutation in the knot can break the intricate signaling within the protein and decrease or even completely shut down the enzymatic activity [9]. Given that the knot is a crucial region of a SPOUT protein, its potential role has been discussed in several studies [5], [10], [...
However, the performance of such approaches is still poor, making practical applications of computational approaches difficult in some fields. Hence, the development of more suitable and efficient computing methods is necessary for identification of essential proteins.In this paper, we propose a new ...
Aryl polyenes (APEs) are specialized polyunsaturated carboxylic acids that were identified in silico as the product of the most widespread family of bacterial biosynthetic gene clusters (BGCs). They are present in several Gram-negative host-associated ba
We reported a partial computational model of the structure which comprises the N-terminus region of the protein (residues 1 to 220)17. That computational model confirmed the GTA fold and allowed the identification of key residues for catalysis and a flexible region involved in acceptor binding, ...
The Drosophila centromeric protein CAL1, found only in the Diptera genus, is essential for CENP-A localization, is recruited to centromeres at a similar time as CENP-A, and interacts with CENP-A in both chromatin and pre-nucleosomal complexes, making it a strong candidate for a CENP-A ...
Accumulating along the length of sensory axons, BPAG1n represents a novel class of cytoskeletal protein that serves a key in vivo role of linking actin and IF arrays. Our findings provide insights into the possible relation of recessive BPAG1 mutations to severe human neurodegenerative disorders. ...
A team led by Ohio State University researchers demonstrated in a bacterial model that a specific protein binds to two sides of a space in the RNA polymerase molecule at a critical point in its connection to DNA, effectively closing thegapand creating a clamp around the two strands. ...
The HHpred analysis identified Gp43 with 100% probability as a distal tail protein (Dit) because it is similar to the Dit protein (PDB 2 × 8K) in the baseplate of the siphophage SPP1, which infectsBacillus subtilis19(Fig. 1). The N-terminal regions of Dit proteins form a hexamer...
By addressing these factors, ACV might indirectly assist in managing essential tremors.How to Use Apple Cider VinegarIf you are considering using apple cider vinegar for essential tremors, it is important to consult with a healthcare professional before making any significant changes to your treatment...