In subject area: Medicine and Dentistry Essential thrombocythemia (ET) is a condition with a platelet level greater than 600 × 109/L, hyperplastic megakaryocytes, and giant platelets with abnormal function. From: Family Medicine Obstetrics (Third Edition), 2008 ...
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MicroRNAs (miRNAs) are a family of well-studied small ncRNAs that regulate gene expression at post-transcriptional level by sequence-specific targeting of mRNAs causing translational repression or mRNA degradation17,18. There is hardly any report but one in plants, on regulation of miRNA expression ...
Similarly, members belonging to the Prevotellaceae family (Phylum, Bacteroidetes) were present in significantly higher numbers in feces of Ffar2−/− mice than WT littermates (Figure 4a). Bacterial members from phyla Firmicutes and Bacteroidetes dominate gut microbiota.37 Firmicutes in gut ...
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are a key link between the innate immune function with the induction of adaptive immunity. dcs are the central regulator of adaptive immunity and immune tolerance, and their discoverer ralph m. steinman was awarded the 2011 nobel prize in physiology or medicine [243]. dendritic cells are ...
(e.g., H3 acetylated at K27) and is therein termed broad epigenetic domain. Genes marked with the broad epigenetic domain are involved in cell identity and essential cell functions and have clinical potential as biomarkers for patient stratification. Reducing expression of genes with the broad ...
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In patient-derived tumor organoids, pharmacological targeting of either serine-synthesis-pathway and LAT1-mediated transport synergizes with amino acid shortage in blunting mutant p53-dependent growth. These findings reveal vulnerabilities potentially exploitable for tackling breast tumors bearing missense TP53...
CaBP1–8 are neuronal Ca2+-binding proteins with similarity to calmodulin (CaM). Here we show that CaBP4 is specifically expressed in photoreceptors, where it is localized to synaptic terminals. The outer plexiform layer, which contains the photoreceptor