Varespladib (LY315920), a specific and effective human non-pancreatic secretory phospholipase A2 (hnsPLA) inhibitor(IC50=7 nM), has been investigated for the treatment and prevention of sickle cell disease, vaso-occlusive crisis, and acute coronary syndrome. 靶点活性 hnsPLA2:7 nM 体外活性 在...
Background The association of elevated serum levels of secretory phospholipase A2 (sPLA2) in patients with cardiovascular disease and their presence in atherosclerotic lesions suggest the participation of sPLA2 enzymes in this disease. The presence of more advanced atherosclerotic lesions in mice that ...
Finally, an interesting series of viewpoints and commentaries address the question of how soon and how intensively lipid-lowering therapy should be applied in primary prevention. Steinberg (262) argued thatatherosclerosisis a progressive life-long disease that results in events only later in life. It...
The disease isthought to be growing in frequency because of the increasing number of inmunocompromised patients.Several mechanisms for the development of splenic abscess may exist. Some studies demostrate that priorsplenic injury in addition to bacteraemia is required for a splenic abscess to occur....
Varespladib methyl in cardiovascular disease. varespladib methylIMPORTANCE OF THE FIELD: The high risk of recurrent cardiovascular events amongst patients with cardiovascular disease receiving evidence-based... RS Rosenson,H Fraser,J Trias,... - 《Expert Opin Investig Drugs》 被引量: 24发表: 2010...
multicintus, Taiwan Island, from the Center of Disease Control, Taipei, Taiwan; (d) B. candidus, Bangkok in Thailand, from Queen Saovabha Memorial Institute, Thailand; (e) B. fasciatus, Peninsular Malaya of Malaysia, from author CHT. All venom samples were in lyophilized Venom lethality ...
Atherosclerosis is a complex disease and in its pathogenesis depends on the interaction between lipoproteins and inflammatory mediators.1 This interaction orchestrates the progression of atherosclerosis from its earliest stage when oxidized lipoproteins and leucocytes penetrate dysfunctional endothelium and enter ...
Artéria EsplênicaAneurismasplenic artery aneurysm is a rare disease whose incidence varies from 1.6% in autopsies of the general population to 7.1% in autopsies of people suffering from portal hypertension.1 it was first describt by beussier 9 in 1770. in most cases the aneurysms are ...
Karakas M, Koenig W (2009) Varespladib methyl, an oral phospholipase A 2 inhibitor for the potential treatment of coronary artery disease. IDrugs 12:585–592Karakas M, Koenig W. Varespladib methyl, an oral phospholipase A2 inhibitor for the potential treatment of coronary artery disease. ...
Spontaneous splenic rupture, which is usually associated with splenic disease, is infrequent. We present two patients, one with pseudocyst and the other with cancer of the pancreas. Both first presented with spontaneous splenic rupture and were treated with splenectomy and distal pancreatectomy. The ...