Although ESCC and EAC differ with regard to pathophysiology, histology, geographical distribution, risk factors, and clinical characteristics, both have 5-year survival rates of less than 20%, underscoring the need for a better understanding of esophageal cancer biology in order to improve patient ...
The immune landscape of esophageal cancer. Cancer Commun (Lond). 2019;39(1):79. Published 2019 Nov 26. doi:10.1186/s40880-019-0427-z 正文 简介 首先介绍食管癌(EC)现状。 世界范围内八大常见癌种以及六大致死性癌症。 主要分型为食管鳞癌(ESCC)以及食管腺癌(EAC),鳞癌在东亚及非洲高发,腺癌在发达...
Esophageal cancer (EC) is the eighth most aggressive malignancy and its treatment remains a challenge due to the lack of biomarkers that can facilitate early detection. EC is identified in two major histological forms namely - Adenocarcinoma (EAC) and Squamous cell carcinoma (ESCC), each showing ...
Esophageal squamous cell carcinoma (ESCC) is malignant while the carcinogenesis is still unclear. Here, we perform a comprehensive multi-omics analysis of 786 trace-tumor-samples from 154 ESCC patients, covering 9 histopathological stages and 3 phases. Proteogenomics elucidates cancer-driving waves in...
G17DT immunogen, cisplatin, 5-FU EC, Gastric cancer III Not provided NCT00020787 Paclitaxel and cisplatin ESCC II Not provided NCT02133612 Docetaxel, cisplatin, leucovorin, and 5-FU Esophageal, Gastroesophageal, Gastric cancer II 2-year survival rate was 9.5% NCT01715233 S1 combined with cisplatin...
Esophageal squamous cell carcinoma (ESCC): advance in genomics and molecular geneticsdoi:10.1111/dote.12088esophagealcancerMicroRNAproteomicstranscriptomicsEsophageal cancer is aggressive and has poor prognosis. Esophageal squamous cell carcinoma (ESCC) is histologically the most prevalent type of esophageal ...
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China has the highest incidence of esophageal squamous cell carcinoma (ESCC). Unlike esophageal adenocarcinoma in western countries, 90% of esophageal cancer in China is squamous cell carcinoma, and there are distinct regional differences. Cancer stem cells, microecology, and epigenetics are closely rel...
ESCC and EAC therapy. Different targeted drugs will bind specifically to their corresponding receptor and affect different downstream signaling pathways, such as the Ras/Raf/MEK/ERK pathway and PI3K/AKT/mTOR pathways. Ultimately, these drugs affect the activity of cancer cells, such as cell ...
Esophageal squamous cell cancer (ESCC) is the major pathologic type of esophageal cancer in Asian population. To systematically evaluate the mutational features underlying clinical characteristics, we establish the integrated dataset of ESCC-META that co