monocephalum ethyl acetate extract afforded a new triterpene lactone Ulubelenolide (olean-12-ene-3β,10β-olide) (1). The structure of (1) was determined with spectral analysis including FTIR, ¹H, 13C NMR, APT, DEPT, COSY, HMQC, HMBC, and APCI-MS.Polatoğlu...
Target site insensitivityImmunohistochemistryCardenolide sequestrationArctiidaeAdaptationDanaus plexippusCardenolides are toxic plant compounds which specifically inhibit Na+/K+-ATPase, an animal enzyme which is essential for many physiological processes, such as the generation of action potentials. Several ...
TOTAL SYNTHESIS OF (±)TANIKOLIDETOTAL SYNTHESIS OF (±)TANIKOLIDEdoi:10.1081/SCC-120005428tanikolidelactonizationsynthesisA total synthesis of (±)tanikolide 1 is described. The six-membered lactone moiety of the title compound was completed through oxidation of α,δ-dihydroxyl compound by PDC.Ru...
Sinulanorcembranolide A, a novel norcembranoidal diterpene from the octocoral Sinularia gaweli[J] . Wei-Hsuan Yen,Yin-Di Su,Yu-Chia Chang,Yu-Hsin Chen,Yung-Husan Chen,Chang-Feng Dai,Zhi-Hong Wen,Jui-Hsin Su,Ping-Jyun Sung.Tetrahedron Letters . 2013 (18)...
Lucking G, Dommel MK, Scherer S, Fouet A, Ehling-Schulz M (2009) Cereulide synthesis in emetic Bacillus cereus is controlled by the transition state regulator AbrB, but not by the virulence regulator PlcR. Microbiology 155:922–931Lucking G, Dommel MK, Scherer S, Fouet A, Ehling-Schulz ...
The total synthesisof the diterpenoids sandresolide B and amphilectolidefrom a common furan building block is presented. Key steps includepalladium-mediated carbonylation, lanthanide catalyzed ring closure,Myers alkylation, intramolecular Friedel–Crafts acylation,photooxygenation, and a Kornblum–DeLaMare ...
University Chemical LaboratoryChristian MoessnerUniversity Chemical LaboratoryChemical CommunicationsSynthesis of twoDiastereomeric C1-C22Fragments of Spirastrellolide A. Paterson, I.,Anderson, E. A.,Dalby, S. M. et al. Chemical Communications . 2007...
Makarasen A, Nishikawa T, Isobe M (2009) Synthesis of four lysine-linked cereulide analogues show- ing ionophoric activity towards potassium cations as lead compounds for emetic toxin-detection by im- munoassays. Synthesis 2009: 2184-2204. doi: 10.1109/IEMBS.2009.5334941 PMID: 19965148...
A convergent and highly stereocontrolled synthesis of amphidinolide E (1) has been accomplished. The synthesis features a highly diastereoselective (>20:1) BF3·Et2O promoted [3+2] annulation reaction between aldehyde 3 and allylsilane 4 to afford substituted tetrahydrofuran 2.Porino...
Here we study reactions of 1with 2-mercaptobenzanilide, 2, a recognized model for the active site of PTP1B. We have characterized crystallographically compound 2and its oxidized sulfenyl-amide derivative 2-phenyl-1,2-benzisothiazol-3(2H)-one (4), which shows a close structural similarity to...