A 50-year-old man developed QT interval prolongation after accidentally ingesting an overdose of dofetilide. The man had been receiving oral dofetilide 250g twice daily, for 5years, to treat paroxysmal atrial f
Sinulanorcembranolide A, a novel norcembranoidal diterpene from the octocoral Sinularia gaweli[J] . Wei-Hsuan Yen,Yin-Di Su,Yu-Chia Chang,Yu-Hsin Chen,Yung-Husan Chen,Chang-Feng Dai,Zhi-Hong Wen,Jui-Hsin Su,Ping-Jyun Sung.Tetrahedron Letters . 2013 (18)...
The article presents a case report involving a 33-year-old man who developed a prolonged corrected QT interval after taking an intentional overdose of dofetilide. It is said that the man took 20 capsules of dofetilide, but then his heart started beating rapidly and did not feel better. It...
AliceDepartmentL.DepartmentRobinsonDepartmentEBSCO_AspPharmacotherapyBova Campbell K, Mando JD, Gray AL, Robinson E.Management of dofetilide overdose in a patient with known cocaine abuse. Pharmacotherapy 27: 459-463, No. 3, Mar 2007 - USA
A convergent and highly stereocontrolled synthesis of amphidinolide E (1) has been accomplished. The synthesis features a highly diastereoselective (>20:1) BF3·Et2O promoted [3+2] annulation reaction between aldehyde 3 and allylsilane 4 to afford substituted tetrahydrofuran 2.Porino...
A novel 2-ketobriarane diterpenoid, briarenolide E (1), was isolated from an octocoral Briareum sp. The structure of briarane 1 was elucidated by interpretations of spectral data. Compound 1 displayed modestly inhibitory effects on the generation of superoxide anions and the release of elastase ...
Dofetilide.The article describes the case of an 83-year-old woman who developed QT interval prolongation because of a dofetilide dose calculation error.EBSCO_AspReactions Weekly
monocephalum ethyl acetate extract afforded a new triterpene lactone Ulubelenolide (olean-12-ene-3β,10β-olide) (1). The structure of (1) was determined with spectral analysis including FTIR, ¹H, 13C NMR, APT, DEPT, COSY, HMQC, HMBC, and APCI-MS.Polatoğlu...
This article presents a case report involving a male patient who developed QT prolongation and torsades de pointes secondary to acute ischemia during treatment with dofetilide for atrial fibrillation. It provides a background on the medical history of the patient. It describes the symptoms presented...
Synthesis and Crystal Structure of (E)-1-(2,3-Dihydroxybenzlidene)-4,4-Dimethythiosemicarbazidedoi:10.1007/s10870-011-0119-223-Dihydroxybenzaldehyde – Thione – Thiolate – Antiparallel – πInteractionsThe Schiff base C10H13N3O2S is monoclinic, having unit cell parameters a...