ionization efficiencyprediction modelsemi-quantitationAs the omics are rocketing we gain insight into the chemical transformations occurring in living beings. The lack of authentic standard substances hinders obtaining deeper quantitative information about these processes. In recent years, artificial intelligence...
纳米电子喷雾电离(nanoESI)的好处之一是,尽管存在基质成分,但化学方法不同的分析的最佳电离效率(均衡响应)据报道。 然而,在大约非常低的流速之外。 1-20 nL / min,电离效率呈指数下降,并且从典型的液相色谱(LC)系统到ESI的较高流速耦合损失了大多数优势,例如...
Recent developments of the methodology have demonstrated that the introduction of charged moieties markedly enhanced the ionization efficiency of neutral steroids in the ESI process. The aim of this study was to develop a simple, more sensitive and reliable method for the analysis of serum sterol pro...
To explore the effect of salts on the ionization efficiency we used a physiological saline solution (154 mM NaCl). In order to examine the performance of the on-line cleanup, the matrix effect of various added matrix components was evaluated for the LC-MS and a FIA-MS analysis. The ...
It is unknown whether this is due to issues with the extraction method or ionization efficiency. The number of oxygens and DBEs trended with carbon number (Fig. 3; Fig. SM-1). While formulae with up to 12 oxygens were identified, most formulae in the lighter carbon number group had ...
determines ionization efficiency I A : Abundance of A in the mass spectrum C A : conc. of A k A : A’s responsefactor ~ ionization efficiency Kebarle P., J. Mass Spectrom. 35, 804-817 (2000) Equimolar mixture of 6 tripeptides with different C-terminal residues Ref. [2] Hydrophilic...
An electrospray ionization (ESI) tandem interface in positive mode was employed prior to mass-spectrometric detection. The method was subjected to a thorough validation procedure in terms of linearity, limit of detection (LOD) and quantification (LOQ), accuracy, and precision. Six-point calibration ...
Advantages over UHPLC-MS include drastically improved sensitivity, improved ionization efficiency and better performance over time of the ionization source. Moreover, CE-MS has the unique feature of simultaneously analysing the parent drugs and their oxidized phase I metabolites [9,10]. However, the...
转格式 78阅读文档大小:644.95K10页1134432上传于2015-05-06格式:PDF 毛细管电泳 热度: 微流控毛细管电泳芯片 热度: 高效毛细管电泳 热度: AnalChem2007(79)9135-9144 FullyMicrofabricatedandIntegratedSU-8-BasedCapillaryElectrophoresis-ElectrosprayIonizationMicrochipsforMassSpectrometry ...
1.An electrospray ionization interface for a mass spectrometer comprising:a glass emitter for electroosmotic flow (EOF) of a sheath-liquid in negative mode, wherein the glass emitter's surface comprises a coating of one or more organic chemicals covalently bonded to the surface wherein the organic...