Escherichia coli O157:H7 is a human pathogen that was first identified from a foodborne outbreak in 1982, and in the 25 years that followed, many new strains were identified and emerged in numerous outbreaks of human disease. Extensive research has been conducted to identify virulence factor ...
Virulence factors of E. coli can affect a wide range of eukaryotic cellular processes, including cell signalling, ion secretion, protein synthesis, mitosis, cytoskeletal function and mitochondrial function. Virulence factors of pathogenic E. coli are frequently encoded on genetic elements such as plasmid...
R. Virulence factor profiles and phylogenetic background of Escherichia coli isolates from veterans with bacteremia and uninfected control subjects. J. Infect. Dis. 190, 2121–2128 (2004). Article PubMed Google Scholar Picard, B. et al. The link between phylogeny and virulence in Escherichia ...
In addition, it has been suggested the significance of ecp in adherence and invasion of uropathogenic Escherichia coli in UTI, being proposed as a key virulence factor in lower UTI (58); while fimH has been described as a factor that allows UPEC not only adherence at the bladder level, but...
Through their unique interactions with eukaryotic cells, adhesion/colonization mechanism, toxin/virulence factor production and clinical disease profiles, the pathogenic E. coli strains are further distinguished into ten pathotypes: enterotoxigenic E. coli (ETEC), enteropathogenic E. coli (EPEC), enterohem...
However, the main virulence factor of EHEC is the phage-encoded Shiga toxin (Stx; also known as verocytotoxin), which is a defining characteristic of the Shiga toxin-producing E. coli (STEC) group to which EHEC O157:H7 belongs. There are two subgroups of Stx, Stx1 and Stx2, which can...
The ssbL Gene Harbored by the ColV Plasmid of an Escherichia coli Neonatal Meningitis Strain Is an Auxiliary Virulence Factor Boosting the Production of Si... (2014). The ssbL gene harbored by the ColV plasmid of an Escherichia coli neonatal meningitis strain is an auxiliary virulence factor ...
coli strains are commensal, some strains encode virulence factors that enable the bacteria to cause intestinal and extra-intestinal clinically-relevant infections. Colibactin, encoded by a genomic island (pks island), and cytotoxic necrotizing factor (CNF), encoded by the cnf gene, are genotoxic ...
as a host receptor forE. colivirulence factor IbeA to facilitate BBB penetration. Genetic ablation of endothelial Caspr1 and blocking IbeA–Caspr1 interaction effectively preventE. colipenetration into the brain during meningitis in rodents. IbeA interacts with extracellular domain of Caspr1 to activate...
Escherichia coli that are capable of causing human disease are often classified into pathogenic variants (pathovars) based on their virulence gene content. However, disease-associated hybrid E. coli, containing unique combinations of multiple canonical v