To the Editor: In their article on last year's outbreak of Escherichia coli O104:H4 in Germany, Frank et al. (Nov. 10 issue)1 report some striking features. Nearly 90% of patients were adults (median age, 42 years), with an overrepresentation of women (68%). In pediatric series, ...
From May to July 2011, one of the largest reported outbreaks of haemolytic uraemic syndrome (HUS) and bloody diarrhoea caused by the Shiga toxin-producing Escherichia coli (STEC) O104:H4 occurred in Germany and France. The hypothetical origin of the outbreak strain was a combined enteroaggregativ...
The enemy within us: lessons from the 2011 European Escherichia coli O104:H4 outbreak. EMBO Mol. Med. 4, 841–848 (2012). Article CAS PubMed PubMed Central Google Scholar Cassini, A. et al. Attributable deaths and disability-adjusted life-years caused by infections with antibiotic-...
coli O104:H4 strains described previously were negative for genetic elements typical of classical EHEC strains, namely the locus of enterocyte effacement (LEE) and the EHEC virulence plasmid (18, 93, 98). The chromosome-encoded LEE pathogenicity island carries the genes (eae and others) coding ...
coli O104:H4), which caused a massive outbreak of acute gastroenteritis and hemolytic uremic syndrome in 2011, carries an aggregative adherence fimbriae I (AAF/I) encoding virulence plasmid, pAA. The importance of pAA in host-pathogen interaction and disease severity has been demonstrated, however...
German outbreak of Escherichia coli O104:H4 associated with sprouts. BACKGROUND: A large outbreak of the hemolytic-uremic syndrome caused by Shiga-toxin-producing Escherichia coli O104:H4 occurred in Germany in May 2011. The... U Buchholz,H Bernard,D Werber,... - 《N Engl J Med》 被引...
O104:H4 combining the adherence properties of enteroaggregativeE. coli(EAggEC) and the production of Vtx, but negative for the AE lesion; therefore not corresponding to the above definition of "EHEC". Nevertheless the O104:H4 strain was often described as an "EHEC bacterium" in the media, ...
In May 2011 one of the worldwide largest outbreaks of haemolytic uraemic syndrome (HUS) and bloody diarrhoea caused by Shiga toxin-producing Escherichia coli (STEC) serotype O104:H4 occurred in Germany. One of the most affected federal states was Lower Saxony. We present the investigation of a...
enterohämorrhagischen Escherichia coli (STEC/EHEC) entwickelt, praktisch erprobt und evaluiert werden. Diese Erreger wurden ausgewählt, da sie als Verursacher von Ausbrüchen mit hohen Morbiditäts- und Mortalitätsraten (wie z. B. der durch den EHEC-Stamm O104:H4 verursachte ...
www.nature.com/scientificreports OPEN The primary transcriptome of the Escherichia coli O104:H4 pAA plasmid and novel insights into received: 01 April 2016 accepted: 27 September 2016 Published: 17 October 2016 its virulence gene expression and regulation Petya Berger1,*, Michael Knödler1,*...