该研究所纳入的患者为经病理确诊的T2-4aN0-1M0的ESCC患者。患者在入组后,通过胃镜活检组织粒,进行基线scRNA-seq单细胞测序,同时接受2~4个周期的新辅助免疫+化疗(白蛋白紫杉醇+卡铂+替雷利珠单抗),在新辅助治疗结束的4~6周内手术。...
Fig. 7: Hsa_circ_0021727 activates TAB1/NFκB signaling via miR-23b-5p. AHeatmap created from mRNA-seq (OE: overexpression, V: vector).BThe top 20 enriched pathways in the mRNA data.CGSEA results showing that hsa_circ_0021727 correlated positively with NFκB signaling.DandEqRT-PCR detecti...
TE-1 cells were treated with miR-NC (20 nM), miR-378d inhibitors (20 nM), and miR-NC added AKT agonist SC79. Then, the a migration and b invasion ability were detected by transwell. TE-1 cells were treated with miR-NC (20 nM), miR-378d mimics (20 nM), and miR-NC added ...
Single-cell RNA sequencing (scRNA-seq) emerges as a powerful, unbiased tool, enabling the classification of cells based on their unique gene expression profiles, independent of any prior genetic or protein markers. This technique provides unparalleled insights into the cellular composition of tumors, ...