Esophageal cancer (EC) is the eighth most aggressive malignancy and its treatment remains a challenge due to the lack of biomarkers that can facilitate early detection. EC is identified in two major histological
1. Qin J, Xue L, Hao A, et al. Neoadjuvant chemotherapy with or without camrelizumab in resectable esophageal squamous cell carcinoma: the randomized phase 3 ESCORT-NEO/NCCES01 trial. Nat Med. 2024;30(9):2549-...
参考文献 [1] Zhang HH, Shen L, Lu ZHH, et al. Clinical efficacy and identification of factors confer resistance to afatinib (tyrosine kinase inhibitor) in EGFR-overexpressing esophageal squamous cell carcinoma. Singnal Transd...
食管癌有两种主要亚型,即食管鳞状细胞癌(Esophageal squamous cell carcinoma, ESCC)和食管腺癌(Esophageal adenocarcinoma, EAC),其中ESCC占总病例的约90%。由于食管癌的早期临床症状并不明显,多数患者往往在就诊时即已发展为晚期。而晚期食管癌往往伴随着转移,这导致食管癌患者死亡率居高不下,在大多数国家食管癌的5年...
Wang B, et al. Personalized mRNA vaccine combined with PD-1 inhibitor therapy in a patient with advanced esophageal squamous cell carcinoma. Am J Cancer Res. 2024 Aug 25;14(8):3896-3904. Zhang C, et al. Current advances in the application of nanomedicine in bladder cancer. Biomed Pharmacot...
2024年5月,中国医学科学院肿瘤医院赫捷院士团队在Drug Resistance Updates(IF 24.3)发表题为“KLF12 Interacts with TRIM27 to affect Cisplatin Resistance and Cancer Metastasis in Esophageal Squamous Cell Carcinoma by regulating L1CAM Expression”的研究文章,揭示了TRIM27/KLF12-L1CAM调控ESCC顺铂耐药和肿瘤转移的...
近日,杂志Nature Communications上发表了一篇题为“Multimodal analysis of cfDNA methylomes for early detecting esophageal squamous cell carcinoma and precancerous lesions”的文章,作者开发了扩展多模态分析(EMMA)方法,同时识别cfDNA样本全基因组亚硫酸盐测序(WGBS)数据中与癌症相关的差异甲基化区域(DMRs)、CNVs和片段...
RTN4IP1通过调控氨基酸转运蛋白的表达促进ESCC发生发展 食管癌有两种主要亚型，即食管鳞状细胞癌（Esophageal squamous cell carcinoma, ESCC）和食管腺癌（Esophageal adenocarcinoma, EAC），其中ESCC占总病例的约90%。由于食管癌的早期临床症状并不明显，多数患者往往在就诊时即已发展为晚期。而晚期食管癌往往伴随着转移，...
[1]Zhang Jing et al., Ribonucleotide reductase small subunit M2 promotes the proliferation of esophageal squamous cell carcinoma cells via HuR-mediated mRNA stabilization, Acta Pharmaceutica Sinica B, https://doi.org/10.1016/j.apsb.2024.07.022 ...
TROAP:食管鳞状细胞癌(ESCC)治疗的新希望 —— 激活 PI3K/AKT 通路推动癌症进展 《Journal of Cancer Research and Clinical Oncology》:TROAP promotes esophageal squamous cell carcinoma progression via the PI3K/AKT pathway 编辑推荐: 食管鳞状细胞癌(ESCC)治疗面临困境,研究人员开展 TROAP 在 ESCC 中作用的...