Immunity-and-matrix-regulatory cells (IMRCs) derived from human embryonic stem cells have unique abilities in modulating immunity and regulating the extracellular matrix, which could be mass-produced with stable biological properties. Despite resemblance to mesenchymal stem cells (MSCs) in terms of self...
Chronic inflammation stimulates fibroblast activation in the extracellular matrix, leading to collagen deposition, tissue remodeling and stenosis formation [179]. The term stricture is often used to describe fibrotic narrowing, with or without an inflamma- tory component [83]. Because CD tends to be...