1. 确定ESC-sEVs对软骨细胞增殖、分化和凋亡的影响:通过体外实验和动物模型,研究ESC-sEVs对软骨细胞增殖、分化和凋亡的影响,探究其调节软骨代谢的机制。 2. 研究ESC-sEVs对软骨细胞炎症反应的调节作用:通过体外实验和动物模型,研究ESC...
Human ESC-sEVs alleviate age-related bone loss by rejuvenating senescent bone marrow-derived mesenchymal stem cellsLiangzhi GongBi ChenJuntao ZhangYongjin SunJi YuanXin NiuGuowen HuYu ChenZongping XieZhifeng Deng
人物简介: 一、郭新民担任职务:郭新民目前担任隰县下李乡新民货运服务法定代表人;二、郭新民投资情况:目前郭新民投资隰县下李乡新民货运服务最终收益股份为0%;老板履历 图文概览商业履历 任职全景图 投资、任职的关联公司 商业关系图 一图看清商业版图 更新时间:2024-05-24...
Thus, ESC-sEVs may be promising therapeutic candidates for age-related diseases.doi:10.1016/j.ymthe.2020.09.037Guowen HuYuguo XiaBi ChenJuntao ZhangZhifeng DengMolecular Therapy
Here, we show that chronic application of human embryonic stem cell-derived small extracellular vesicles (hESC-sEVs) rescues the function of senescent bone marrow mesenchymal stem cells (BM-MSCs) and prevents age-related bone loss in ageing mice. Transcriptome analysis revealed that hESC-sEVs ...