最初在 1982 年时,在阿根廷发现 K. pneumoniae 身上有破坏 cefotaxime 的 ESBL。1983 年德国也发现类似菌株。而 ESBL 基因也藉由质体传到 E. coli 及 K. oxytoca 菌株,现今大部份的 ESBL 是由此三株菌产生,但其他可以产生 ESBL 的细菌包括 Proteus spp.、Serratia spp.、Citrobacter...
[4] Li X M,Jang S J, Bae I K, et al. [Frequency of extended-spectrum beta-lactamase (ESBL)and AmpC beta-lactamase genes in Escherichia coli and Klebsiella pneumoniaeover a three-year period in a University Hospital in Korea][J]. ...
pneumoniae is seriously high, the most frequent type of -lactamase in K. pneumoniae was the MBL, followed by ESBL. The application of infection control measures and antimicrobial stewardship are highly recommended to decrease emergence and spread of drug-resistant strains...
ESBL检测的临床意义 一、革兰阴性杆菌的主要耐药问题是产酶 b-lactamase-mediatedResistance:EvolutionintheClinicalSetting 1940s Penicillins Penicillinases Narrow-spectrumcephems Broad-spectrumβ-lactamases S.aureus,H.influenzae,N.gonorrhoeaeM.catarrhalis,V.cholerae,EnterobacteriaceaeP.aeruginosa,Acinetobacter Expanded...
Molecular epidemiology of a citywide outbreak of extended-spectrum b-lactamaseproducing Klebsiella pneumoniae infection. Clin Infect Dis 2002; 35:83441.产ESBLs菌株血行感染:病死率增加的危险因素之一广谱头孢菌素的治疗Bloodstream Infections Due to Extended-SpectrumBeta-Lactamase-Producing Escherichia col 19、...
ESBL介绍 微生物学分类 •肠杆菌科革兰氏阴性菌 –大肠杆菌E.coli–肺炎克雷伯菌Klebsiellapneumoniae,产酸克雷伯菌K.oxytoca –肠杆菌属Enterobacter,枸橼酸杆菌属Citrobacter,沙雷氏菌属Serratia •非发酵革兰氏阴性菌 –绿脓杆菌Pseudomonasaeruginosa–不动杆菌Acinetobacterspp.–嗜麦芽窄食单胞菌Stenotrophomonas...
[13]. Jansaker F,et al. Clinical and bacteriological effects of pivmecillinam for ESBL-producingEscherichia coliorKlebsiella pneumoniaein urinary tract infections. J Antimicrob Chemother 2014; 69:769–72. 编辑:盛滋科 专家审核:谢青
To genetically characterize clusters of virulence factors (VFs) among extended spectrum β-lactamase (ESBL)-producing Escherichia coli and Klebsiella pneumoniae and assess whether these clusters are associated with genetic determinants or clinical outcomes.One hundred forty-eight E. coli and 82 K. pneumo...
K. pneumoniae 酶抑制剂复合制剂的地(Di)位 ➢ 轻中度感染:可选择头孢哌酮/舒巴坦,哌拉(La)西林/他唑 巴坦 ➢ 需加大剂量使用:头孢哌酮/舒巴坦2g/3g,q8h;哌拉西 林/他唑巴坦4.5h,q6h ➢ 其他β-内酰胺/β-内酰胺酶复合制剂不推荐使用 浙江大学医学院附属邵逸夫医院 32 第三十二页,共六十八页。