The hormone erythropoietin is a substance that regulates the formation of red cells in the hemopoietic tissues of the body. It has been shown that under conditions of anoxic stress due to anemia, low atmospheric O 2 tension or any other cause an erythropoietic factor is demonstrable in the ...
Mechanism of action Erythropoietin or exogenous epoetin alfa binds to the erythropoietin receptor (EPO-R) and activates intracellular signal transduction pathways 3. The affinity (Kd) of EPO for its receptor on human cells is ∼100 to 200 pM 4. Upon binding to EPO-R on the surface of eryth...
This should facilitate the study of the mechanism of action of Ep and lead to a better understanding of erythropoiesis. The coming availability of Ep for therapeutic use will create new approaches to the management of many patients who now require red cell replacement transfusions.关键词:...
This educational activity highlights the mechanism of action, adverse event profile, pharmacology, monitoring, and relevant interactions of ESAs, comparing them to the physiology of natural erythropoietin. Additionally, this discussion covers the FDA-issued box warnings, administration, and toxicity of ESAs...
22. Elliott S, Pham E, Macdougall IC, Elliott S, Pham E, Macdougall IC: Erythropoietins: a common mechanism of action. Exp Hematol 2008, 36:1573-84. 23. Salahudeen AK, Haider N, Jenkins J, Joshi M, Patel H, Huang H, et al: Antiapoptotic properties of erythropoiesis-stimulating ...
In this review we summarize the structural and molecular features, the mechanisms of production and of metabolism, the more important methods of assay, the mechanism of action and the biological effects, the main pathophysiological aspects and the therapeutic usefulness of the hormone....
Its nature and mechanism of action. In: Wirkungsmechanismen der Hormone, S. 197–213. Berlin-HeidelbergNew York: Springer 1967. Google Scholar Dyke, D. C. Van, M. L. Nohr, and J. H. Lawrence: Blood 28, 535–543 (1966). PubMed Google Scholar Engelbrecht, H., W. Remmele: ...
Erythropoietin's function is mediated through its receptor and includes proliferation, survival, and terminal differentiation of CFU-E cells. The mechanism of oxygen sensing and signal transduction that leads to activation of the erythropoietin gene and erythropoietin synthesis in renal cells involves the...
We observed an increased apoptosis at day 4 in the cells that underwent proliferation and differentiation at 20% oxygen, however the underlying mechanism is not clear. Depending on the severity of hypoxia it can have differential effects on the apoptosis. On the one hand it was proven to be ...
A link to download a PDF version of the drug profile will be included in your email receipt. At a glance Originator Neose Technologies Class Antianaemics; Polyethylene glycols; Recombinant erythropoietins; Recombinant fusion proteins Mechanism of Action Erythropoiesis stimulants; Erythropoietin rec...