During erythroid maturation, where high quantities of the holocomplex of hemoglobin has to be produced, as well the proper folding along with the prosthetic groups of heme, HSPs have specified roles (Weiss and dos Santos, 2009). In particular, HSP70 is implicated in the protection of GATA-1 ...
Microfluidic constriction channels that resemble micropipettes have also been developed for measuring the deformability of single RBCs in a high-throughput manner (Figure 1B)[22]. A 2D microfluidic constriction array, for example, is capable of measuring the deformability of 104cells simultaneously[22...
When carefully checking the cartilage growth plates of neonatal mice, we observed a type of eosin-positive structure in the hypertrophic chondrocytes. The size and shape of the structures were similar to those of RBCs in the bone marrow as confirmed by scanning electron microscopy (Fig.1a). The...
Beta-thalassaemic and non-beta thalassaemic erythrocytes were diluted into culture medium at 0.01% Hct, and their membrane thermal fluctuations were recorded with the set-up described above at high frame rate (fps < 500 frames per s) and short exposure time (0.8 ms) for 20 s, with ca...
By a series of formulation optimizations, spherical PTX nanoparticles (PN) with the particle size of around 280nm were successfully cloaked in erythrocyte membrane, resulting in a PTX-NP-EM (PNM) system. The PNM could achieve high drug loading of PTX (>60%) and stabilize the particle size ...
CONCLUSION Improving the oxygen utilization rate of red blood cells by increasing the oxygen affinity of erythrocytes under hypobaric and hypoxia environment is the starting point and focus of the current research on preventing the damage of high altitude hypobaric and hypoxic environment to the human ...
In the small size range (pores 2.6–3 μm), the relative resistance falls from a high value at low ΔP s to an asymptotic value that depends on hematocrit at high ΔP. Using a model for cellflow in the pores, an estimate for the apparent membraneviscosity is attained which is a ...
We found that its property of rosette disruption was associated, to some extent, with size (high molecular weight) but not with its anticoagulant potential (affinity for antithrombin III). A heparin fraction with low affinity for antithrombin III and one with combined high molecular weight and ...
Erythrocytes can be classified by their size and hemoglobin concentration on the basis of quantitative parameters such as the mean corpuscular volume (MCV, the average cell size), the red cell distribution width (RDW), and the mean corpuscular hemoglobin concentration (MCHC). Macrocytosis, normocyt...
A special aerosol generator (SPAG-2, ICN Pharmaceuticals) is needed to produce particles of proper aerodynamic size to reach the lower respiratory tract. The delivered dose is twice as high in infants (1.8 mg/kg/hr) than in adults. Show moreRead full chapterView PDFExplore book Global ...