During erythroid maturation, where high quantities of the holocomplex of hemoglobin has to be produced, as well the proper folding along with the prosthetic groups of heme, HSPs have specified roles (Weiss and dos Santos, 2009). In particular, HSP70 is implicated in the protection of GATA-1 ...
Microfluidic constriction channels that resemble micropipettes have also been developed for measuring the deformability of single RBCs in a high-throughput manner (Figure 1B)[22]. A 2D microfluidic constriction array, for example, is capable of measuring the deformability of 104cells simultaneously[2...
By a series of formulation optimizations, spherical PTX nanoparticles (PN) with the particle size of around 280nm were successfully cloaked in erythrocyte membrane, resulting in a PTX-NP-EM (PNM) system. The PNM could achieve high drug loading of PTX (>60%) and stabilize the particle size ...
When carefully checking the cartilage growth plates of neonatal mice, we observed a type of eosin-positive structure in the hypertrophic chondrocytes. The size and shape of the structures were similar to those of RBCs in the bone marrow as confirmed by scanning electron microscopy (Fig.1a). The...
High frequency of tetraploidy was noticed in specimens from a commercial dealer, no tetraploidy was observed among specimens from wild populations, and one example was found among specimens from a fish farmer. The occurrence of triploidy was not unusual in any of these specimens. 展开 ...
Although Lands’ cycle was discovered in 1958, its function and cellular regulation in membrane homeostasis under physiological and pathological conditions remain largely unknown. Nonbiased high throughput metabolomic profiling revealed that Lands’ cycl
The concentration of GSH-Px varied between 500 to 1 800 wkat/1 red cells and the distribution revealed a bimodality despite the same diet and selenium intake. The peroxidase activity of the sheep erythrocytes was classified high if it was > 1 000 wkat/1 or low if it was < 1 000 ttk...
Erythrocytes can be classified by their size and hemoglobin concentration on the basis of quantitative parameters such as the mean corpuscular volume (MCV, the average cell size), the red cell distribution width (RDW), and the mean corpuscular hemoglobin concentration (MCHC). Macrocytosis, normocyt...
Sheep erythrocytes are used because of the high levels of the polyanion, sialic acid, on the cell surface, which allows them to be very effectively protected by FH. Thus, these erythrocytes are resistant to the AP. This assay also requires Ca++ for stability of C1 and Mg++ for stability ...
Bielekova et al., “Expansion and Functional Relevance of High-Avidity Myelin-Specific CD4 T Cells in Multiple Sclerosis,” J Immunol 2004; 172:3893-3904. Bigbee et al., “ Binding specificities of eight monoclonal antibodies to human glycophorin A—studies with McM, and MkEn(UK) variant ...