The most common manifestations include rash, arthritis and fatigue. At the more severe end of the spectrum, SLE can cause nephritis, neurological problems, anaemia and thrombocytopaenia. Over 90% of patients with SLE have positive anti-nuclear antibodies (ANA). Significant titres are accepted to ...
The presence of a malar rash is a classic finding in SLE (Fig. 12). The rash can be raised or flat, and may be pruritic or painful. The absence of papules, pustules, and comedones helps to differentiate it from acne rosacea or acne vulgaris. The indolent and intermittent presentations of...
Malar rash: butterfly shape, flat, non-tender erythematosus rash over the cheek and nose a) Photograph of a face with skin rashes sparing the bridge of the nose and malar area. b) Photograph of a face showing asymmetric hyperpigmented, polycylic, and annular scaly plaques with scaling invol...
Rash shaped like butterfly wings Sensitivity to sunlight Hair loss Mouth or nose sores Painful joints Chest pain or cough when you take a deep breath Abdominal pain, nausea, or vomiting How is lupus diagnosed? Blood testsare used to check for signs of infection, inflammation, or anemia (low...
Systemic lupus erythematosus (SLE) is a highly prevalent human autoimmune diseases that causes progressive glomerulonephritis, arthritis and an erythematoid rash. Mice deficient in deoxyribonuclease I (Dnase1) develop an SLE-like syndrome. Here we describe two patients with a heterozygous nonsense mutati...
The classic presentation of a triad of fever, joint pain, and rash in a woman of childbearing age should prompt investigation into the diagnosis of SLE. [2] However, male or female patients may present at any age with any of the following manifestations [3] : Constitutional (eg, fatigue,...
“butterfly rash” (fixed reddish and flat rash that extends over both cheeks and the bridge of the nose). Other symptoms may include maculopapular rash (small, colored area with raised red pimples), sensitivity to the sun, photophobia, vascular skin lesions, leg ulcers, oral ulcers, and ...
As seen in many patients with lupus, the hallmark "butterfly rash" appears... AOn the chest or back BAcross the nose and cheeks CAcross the pelvis DBetween the shoulder blades The correct answer is:Across the nose and cheeks Explanation: ...
with up to 75% of patients experiencing them at some point and 25% at diagnosis. The most typical cutaneous manifestation is a malar rash resembling a butterfly on the nose and cheeks, accompanied by photosensitivity, oral/nasal ulcers, scarring discoid lesions and non-scarring alopecia [98]...
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