Ertapenem for injection 15 mg/kg IV twice daily up to a maximum of 1 g or ceftriaxone 50 mg/kg/day IV in two divided doses up to a maximum of 2 g, and patients 13 to 17 years of age received Ertapenem for injection 1 g IV daily or ceftriaxone 50 mg/kg/day IV in a single ...
Children 3 months-12 years: 15 mg/kg IV/IM every 12 hours up to 14 days; not to exceed 1g every 12 hours; after 3 or more days of parenteral therapy, may be switched to appropriate oral regimen if patient improves clinically Children older than 12 years of age: 1 g/day IV/IM up ...
No accumulation of ertapenem was seen at steady state following intravenous or intramuscular administration; the mean bioavailability of the drug following intramuscular administration is ≈90%. Ertapenem is highly plasma protein bound in a nonlinear concentration-dependent manner, and achieves good penetrati...
It is supplied as a lyophilized powder in a vial, which requires reconstitution for IV/IM administration. Pre-clinical studies demonstrated poor oral bioavailability in rodents ( < 6%), reflecting poor oral absorption from the GI tract. Oral administration of 500 mg/kg ertapenem in mice (35-...
Oral Moxifloxacin vs IV Ertapenem Plus Oral Levofloxacin for Uncomplicated Acute Appendicitis View LargeDownload Figure 1. Flow of Patients in a Study of the Effect of Oral Moxifloxacin vs Intravenous Ertapenem Plus Oral Levofloxacin for Uncomplicated Acute Appendicitis View LargeDownload aIncludes ...
Children older than 12 years of age: 1 g/day IV/IM up to 14 days; after 3 or more days of parenteral therapy, may be switched to appropriate oral regimen if patient improves clinically Acute Pelvic Infections Adult dosage 1 g/day IV/IM for 3-10 days ...
On day 5, her antibiotic therapy was switched to IV ertapenem 1 g/day, and carbamazepine was replaced with oral valproic acid 400mg three times daily due to suspected drug-fever. Her fever resolved on day 16 and ertapenem was stopped. At that time, her serum valproic acid concentration was...
METHODS. ADAPT-PO was a global, double-blind, Phase 3 study to evaluate the efficacy and safety of oral TBP-PI-HBr vs. IV ertapenem in hospitalized adult patients with cUTI or AP. The primary endpoint was overall response (composite clinical cure and microbiologic eradication) at the test-...
After at least 3 days of IV therapy and satisfactory clinical response, patients could be switched to oral ciprofloxacin plus metronidazole. Fifty-nine patients were randomized to receive ertapenem 1 g and 51 to receive ertapenem 1.5 g; 55 patients were randomized to each comparator group. At ...
Intravenous (IV) to oral (PO) antibiotic step-down therapy has many benefits including reducing the length of hospital stay and lowering the risk of nosocomial infections and overall cost. While fluoroquinolones have been utilized as a step-down therapy for urinary tract infections (UTI) for some...