fumigatus. Inactivation of Erg24 leads to the disruption of ion homeostasis and affects ergosterol biosynthesis.doi:10.1007/s00253-021-11104-5Yeqi LiMengyao DaiYuanwei ZhangLing LuApplied Microbiology and Biotechnology
7.15.2.2 Ergosterol Biosynthesis Like cholesterol, ergosterol is biosynthetically derived from acetyl-coenzyme A (CoA: Figure 1). The nine biosynthetic steps leading to the first sterol intermediate, lanosterol, are identical in both pathways; related enzymes in fungi and mammalian cells catalyze all...
Azoles interfere with the biosynthesis of the main fungal sterol, ergosterol, leading to a reduction in ergosterol production and an accumulation of lanosterol and 14-methylated sterols in the plasma membrane [[5], [6], [7]]. Azoles inhibitory effects can be attributed to their binding to cyt...
Erg4A and Erg4B Are Required for Conidiation and Azole Resistance via Regulation of Ergosterol Biosynthesis in Aspergillus fumigatus.doi:10.1128/AEM.02924-16Nanbiao LongXiaoling XuQiuqiong ZengHong SangLing LuAmerican Society for Microbiology
Partition experiments by fluorescence spectroscopy showed a decrease in Trp42 quantum yield of Psd2 in the presence of GlcCerF.solani and Erg, individually or in simultaneously enriched membranes. The partition coefficient (Kp) obtained indicated a Psd2 partition preference for this vesicles, confirmed...
There have been no reports on the role of this protein family in the regulation of ergosterol biosynthesis. The main objectives of this study were as follows: (1) to identify and localize the VdKeR1 protein in V. dahliae, (2) to investigate the role of VdKeR1 in the growth and ...
cerevisiae (Figure 4). The two FSSC species F. solani and F. vanettenii had the same eight duplicates as F. keratoplasticum and three cyp51 genes. A. fumigatus had nine ergosterol biosynthesis gene duplicates (erg10, erg13, hmg, erg7, cyp51, erg24, erg25, erg26 and erg4) and ...
Biosynthesis Metabolism Transferase Q8GYA4 Signaling Transferase 1113.626 1142.642 973.531 928.535 1223.667 −0.6 0.4 0.3 −2.9 0.0 F4JXW9 Biosynthesis — 992.541 1.2 Q944A7 P48347 Q39033 O80452 Defense Signaling Defense Transferase Protein binding Hydrolase Response Hydrolase 1269.741 1229.580 996.645 ...