10 Based on developmental cohort results, thresholds of T2:ERG score greater than 8, PCA3 score greater than 20, or serum PSA level greater than 10 ng/mL as a positive test result were prespecified for the validation analysis. The validation analysis confirmed that overexpression of either urine...
These results indicated that BRD2 also promotes the repair of DNA DSBs by NHEJ. We tested the role of BRD2 in CRISPR-Cas9-mediated TMPRSS2-ERG gene fusion formation. BRD2 knockdown using multiple siRNAs either individually or pooled, resulted in a significant block in TMPRSS2-ERG gene ...
Journals & Books Help Search My accountSign in View PDF Download full issue Search ScienceDirect Outline Abstract Introduction Methods Results Discussion Acknowledgments Supplementary Material Authorship ReferencesShow full outline Figures (5) Extras (2) Download all ...
We used a multi-institutional prostate cancer tissue microarray constructed from radical prostatectomy samples with associated detailed clinical data and with rigorous selection of recurrent and non-recurrent cases to test the prognostic value of immunohistochemistry staining results for the ERG and SPINK1 ...
position of the curves before adding hormone was clearly displaced to positive voltages in the cells expressing the dominant-negative form of Gq (Fig. 8A). This complicates the interpretation of the dominant-negative Gq influence on the hormonal effect in the I–V relation. Finally, expression ...
performed experiments and discussed the experimental findings and interpreted the results. M.F., T.O., Y.O. collected clinical information from H.C.C. patients and analyzed the data. M.F., T.O., T.Y. discussed the interpretation of the results. All authors reviewed the manuscript. ...
SM-102 (1-octylnonyl 8-[(2-hydroxyethyl)[6-oxo-6-(undecyloxy)hexyl]amino]-octanoate) is an amino cationic lipid that has been tailored for the formation of lipid nanoparticles and it is one of the essential ingredients present in the ModernaTM COVID-19 v
This requires a little bit more effort as it’ll require high-level interpretation especially in terms of how you plan on marketing a specific product or service. It’s also one of the most effective forms of marketing as consumers become easily influenced by every jingle, logo or practically...
Despite the high sensitivity (> 80%) of FISH and IHC, sample fixation tech- niques, reference settings, and reagent batches all have an impact on the results [14, 15]. Besides, semi-quantitative and subjective positive interpretation criteria also lead to poor reproducibility of detection ...