doi:10.1007/978-3-642-16483-5_1981The mechanism whereby unfolded or misfolded proteins are reexported from the endoplasmic reticulum lumen into the cytosol to undergo proteasomal degradation. Endoplasmic Reticulum StressManfred SchwabSpringer Berlin HeidelbergEncyclopedia of Cancer...
内质网相关蛋白降解(ER-associated protein degradation,或ER-associateddegradation,ERAD)是真核细胞蛋白质质量控制的重要途径,它承担着对错误折叠蛋白的鉴别、分检和降解,清除无功能蛋白在细胞内的积累。
ERdj4 Protein Is a Soluble Endoplasmic Reticulum (ER) DnaJ Family Protein That Interacts with ER-associated Degradation Machinery ERdj4 protein is a soluble endoplasmic reticulum (ER) DnaJ family protein that interacts with ER-associated degradation machinery. The Journal of biological ... CW Lai,JH...
ER-Associated Protein Degradation Pathways英文学习资料 .PDF,SnapShot: ER-Associated Protein Degradation Pathways Shinichi Kawaguchi and Davis T.W. Ng Temasek Life Sciences Laboratory and Department of Biological Sciences, National University of Singapore
摘要: Endoplasmic reticulum-associated protein degradation (ERAD) is a cellular process that targets short-lived resident proteins and aberrant secretory proteins to the proteasome for degradation. ERAD is...DOI: 10.1007/978-1-4419-6382-6_14 年份: 2011 ...
The loss of Env was found to result from GPG-NH2 targeting the Env precursor protein gp160 to the ER-associated protein degradation (ERAD) pathway during its maturation. However, the anti-viral effect of GPG-NH2 has been shown to be mediated by its metabolite ??-hydroxy-glycineamide (??
The endoplasmic reticulum (ER) of the cell operates a quality control system that identifies misfolded proteins, transports them into the cytoplasm and then targets them for degradation by the proteasome. Aberrant protein degradation is the mechanism underlying many diseases, including cystic fibrosis and...
Endoplasmic reticulum (ER)-associated protein degradation requires the dislocation of selected substrates from the ER to the cytosol for proteolysis via the ubiquitin–proteasome system. The AAA ATPase Cdc48 (known as p97 or VCP in mammals) has a crucial, but poorly understood role in this transp...
The endoplasmic reticulum (ER) of the cell operates a quality control system that identifies misfolded proteins, transports them into the cytoplasm and then targets them for degradation by the proteasome. Aberrant protein degradation is the mechanism underlying many diseases, including cystic fibrosis and...
Endoplasmic reticulum (ER)-associated protein degradation (ERAD) is a quality control system that removes misfolded proteins from the ER1,2. ERAD substrates are channelled from the ER via a proteinacious pore to the cytosolic ubiquitin–proteasome system — a process involving dedicated ubiquitin li...