Poor nutrition during perinatal period, especially protein malnutrition, is associated with increased risk for MS in later life. Here, we analyzed the effects of taurine (TAU) supplementation upon insulin secretion and ER stress marker expression in pancreatic islets and in the liver from mice fed ...
Glucose-regulated protein of 78 kD (GRP78) also referred to as immunoglobulin heavy chain binding protein (BiP/GRP78) plays an important role in the endoplasmic reticulum (ER) stress. The level of BiP/GRP78 is highly elevated in various human cancers. The purpose of this study is to examin...
ER stress 相关基因 常用的ER stress marker 有ATF6、XBP1、PERK、IRE1alpha、eIF2alpha、ATF4(ER stress 通路中的基因)、GRP78/Bip、PDI、GRP94（内质网的分子伴侣）CHOP(C/EBP 的同源蛋白，是内质网应激源性的)其中eIF2alpha，GRP78、PDI、GRP94、在睾丸蛋白谱中都没有明显改变 1、CASP8: caspase8 凋亡...
1、常用的ER stress marker 有ATF6、XBP1、PERK、IRE1alpha、eIF2alpha、ATF4(ER stress 通路中的基因)、GRP78/Bip、PDI、GRP94(内质网的分子伴侣)CHOP(C/EBP 的同源蛋白,是内质网应激源性的)其中eIF2alpha,GRP78、PDI、GRP94、在睾丸蛋白谱中都没有明显改变1、CASP8: caspase8 凋亡相关蛋白 2.141666ER stre...
(e)expression of the ER stress marker proteins CHOP and BiP in control and KO1 cells upon different activation periods with PMA/Iono.(f,g)Immunoblotting for phospho-Jnk and Bim expression upon addition of the protein synthesis inhibitor cycloheximide (20 µg/ml) for 0, 1, 3 and 6 ...
transfected SH-SY5Y cells and accumulated in 3 × Tg-AD mice neurons [72]. HSPA5 is an ER stress marker, upregulation of which is indicative of ER stress induction owing to the accumulation of toxic turn Aβ [72]. Therefore, these findings indicate that intraneuronal aggregation of ...
PRKR-like endoplasmic reticulum kinase (PERK) is one of the major sensor proteins that detect protein folding imbalances during endoplasmic reticulum (ER) stress. However, it remains unclear how ER stress activates PERK to initiate a downstream unfolded protein response (UPR). Here, we found that...
Homocysteine‐induced endoplasmic reticulum protein (Herp) is up‐regulated in sporadic inclusion‐body myositis and in endoplasmic reticulum stress‐induc... Herp is a stress-response protein localized in the endoplasmic reticulum (ER) membrane. Herp was proposed to improve ER-folding, decrease ER pr...
Protein Kinase CK2ER StressSignallingThe endoplasmic reticulum is the central organelle within a eukaryotic cell where newly synthesized proteins are processed and properly folded. An excess of unfolded or mis-folded proteins induces ER stress signalling pathways. Usually this means a pro-survival ...
Increase in ER stress marker proteins after pharmacological inhibition f and genetic knockdown g of PFKFB3 as demonstrated by Western blot Full size image A time-dependent upsurge of intracellular Ca2+ in MPM cells As inhibition of glycolysis can lead to calcium overload30,31, we further measured...