2010年,ASCO和美国病理学家学会的指南将ER阳性的病理诊断变更为≥1%的肿瘤细胞核着色,Choong博士解释说。该指南还承认,ER低表达状态(1%-10%染色)的患者人群与三阴性乳腺癌(triple-negative breast cancer, TNBC)患者的特征更相似。 具体...
参考文献: 【1】Sun, X., Tang, H., Chen, Y. et al. Loss of the receptors ER, PR and HER2 promotes USP15-dependent stabilization of PARP1 in triple-negative breast cancer. Nat Cancer (2023). https://doi.org/10.1038/s43018-023-00535-w...
研究显示,ER低表达与ER阴性或基底样乳腺癌的分子特征相似[14, 20]。有研究发现,ER低表达患者的年龄、种族、家族史、肿瘤大小、分期或肿瘤分级等与三阴性乳腺癌(triple-negative breast cancer,TNBC)患者比较差异无统计学意义(P>0.05),且与TNBC胚系突变相似,BRCA1/BRCA2是最常见的突变基因[14]。也有研究发现,ER...
10 Toi M, Imoto S, Ishida T, et al. Adjuvant S-1 plus endocrine therapy for oestrogen receptor-positive, HER2-negative, primary breast cancer: a multicentre, open-label, randomised, controlled, phase 3 trial. Lancet Oncol. 2021...
Harmful effect of ERbeta on BCRP-mediated drug resistance and cell proliferation in ERalpha/PR-negative breast cancer. FEBS J. 2013; 280:6128-6140.Li W, Jia M, Qin X, Hu J, Zhang X and Zhou G: Harmful effect of ERβ on BCRP-mediated drug resistance and cell proliferation in ERα/...
三阴性乳腺癌(Triple Negative Breast Cancer, TNBC)指的是一种缺乏雌激素受体(ER)、孕激素受体(PR)和HER2受体的乳腺癌类型。这种类型的乳腺癌更具侵袭性,且缺乏激素治疗和HER2靶向治疗的靶点,因此治疗选择较为有限,传统的化疗仍是其主要治疗手段。但近年来,靶向药物和免疫疗法的不断创新为该疾病的治疗带来了新希望...
The immunohistochemically "ER-negative, PR-negative, HER2-negative, CK5/6-negative, and HER1-negative" subgroup is not a surrogate for the normal-like subtype in breast cancerYu, K.-D.; Shen, Z.-Z.; Shao, Z.-M.Breast Cancer Research and Treatment 118(3): 661-663...
[15,37,38] Interestingly, members of the miRNA-30 family (a, b, c and 30a-5p) were found to be downregulated in ER-negative and PR-negative tumors.[14] Other studies have also demonstrated a correlation between expression of miRNA signatures and ER/PR status in breast cancer and these ...
Nineteen ER/PR-negative breast cancer survivors with a mean age of 59 years participated in the study. All but two of the participants completed the 12-week intervention. Women lost an average of 6.3 卤 4.9 kg (P < 0.001), equivalent to 7.5% of their baseline weight. There were ...
Risk of estrogen receptor (ER)-negative, progesterone receptor (PR)-negative breast cancer is reduced in women who breastfeed and use of oral contraceptives (OCs) does not raise the risk of the disease. So say findings from a population-based study presented at the...