Here, we assess the ability of NLC derived from ER-HoxB8 progenitors to produce ROS and to perform chemotaxis and phagocytosis. We compare the Ca2+ responses and effector functions of NLC to primary murine neutrophils and document the molecular basis of their functional differences by mRNA ...
Here, we assess the ability of NLC derived from ER-HoxB8 progenitors to produce ROS and to perform chemotaxis and phagocytosis. We compare the Ca2+ responses and effector functions of NLC to primary murine neutrophils and document the molecular basis of their functional differences by mRNA ...
Mechanisms controlling differentiation and self-renewal of IL-3 dependent ER-Hoxb8 myeloid progenitorsPlacentaHumansTrophoblastsInsulin-Like Growth Factor IIRNA, UntranslatedReproductive Techniques, AssistedGene Expression RegulationAdultInfant, NewbornAllelesAuthor Summary We have screened a population of ...
We also used the ER-Hoxb8 system (estrogen receptor fused to Hoxb8) of conditional immortalization to establish a new murine model system for the ex vivo study of TAFAZZIN-deficient neutrophils. The TAFAZZIN-KO cells demonstrated the expected dramatic differences in cardiolipin maturation that result...