MatrixEQTL是一个快速有效的cis/trans eQTL mapping分析工具,被The Genotype-Tissue Expression (GTEx)数据库用于eQTL mapping分析。使用MatrixEQTL进行eQTL mapping需要五个输入文件,即SNP.txt(snpmatrix文件,行名为样本名称,列名为snpid),GE.txt(基因表达量文件,行名为样本名称,列名为基因或者转录本名称),Covariates....
此外,了解免疫系统调节的遗传基础将对自身免疫性疾病、感染、移植和癌症的治疗产生广泛影响。 [1] Yazar S, Alquicira-Hernandez J, Wing K, et al. Single-cell eQTL mapping identifies cell type-specific genetic control of autoimmune disease. Science. 2022;376(6589):eabf3041. doi:10.1126/science.abf30...
今天要分享一个新的内容,文章在Single-cell eQTL mapping identifies cell type–specific genetic control of autoimmune disease,2022年4月8日发表在Science期刊,其中有一些新的内容,表达数量性状位点(eQTL),单细胞和eQTL的联合分析,非常值得一读和分享。 首先我们要先了解一下eQTL是什么 表达数量性状位点(expression ...
eQTLs, the discovery of genetic variants that explain variation in gene expression levels. An eQTL is a locus that explains a fraction of the genetic variance of a gene expression phenotype. Standard eQTL analysis involves a direct association test between markers of genetic variation with gene expr...
eQTL mapping using the GWAS approach is that it permits the identification of new functional loci without requiring any previous knowledge about specificcisortransregulatory regions. Typically in the eQTL mapping literature, regulatory variants have been characterized as eithercisortransacting, reflecting ...
eQTL mapping identifies insertion- and deletion-specific eQTLs in multiple tissues. Nat Commun 6, 6821 (2015).JinyanHuang, JunChen, JorgeEsparza, JunDing, James T.Elder, Goncalo R.Abecasis, Young-AeLee, G.Mark Lathrop, Miriam F.Moffatt, William O. C.Cookson, LimingLiang. (2015) eQTL ...
Integrating genetic and gene expression data: methods and applica-tions of eQTL mapping LIU Gang, PENG Hui-Ru, NI Zhong-Fu, QIN Dan-Dan, SONG Fang-Wei, SONG Guang-Shu, SUN Qi-Xin Department of Plant Genetics & Breeding and State Key Laboratory for Agrobiotechnology , Key Laboratory of ...
相关研究结果发表在2022年4月8日的Science期刊上,论文标题为“Single-cell eQTL mapping identifies cell type–specific genetic control of autoimmune disease”。 这些作者开发了一个细胞分类框架,并通过结合scRNA-seq数据和基因型数据,他们绘制了14种免疫细胞类型中每种类型的基因表达的遗传效应,并确定了26597个独立...
Elasticsearch:Dynamic mapping 2019-12-23 14:30 − Elasticsearch最重要的功能之一是它试图摆脱你的方式,让你尽快开始探索你的数据。 要索引文档,您不必首先创建索引,定义映射类型和定义字段 - 您只需索引文档,那么index,type和field将自动生效。比如: PUT data/_doc/1 { "count": 5 } 上... 哈喽哈喽...
Integrating genetic and gene expression data: methods and applica-tions of eQTL mapping LIU Gang, PENG Hui-Ru, NI Zhong-Fu, QIN Dan-Dan, SONG Fang-Wei, SONG Guang-Shu, SUN Qi-Xin Department of Plant Genetics & Breeding and State Key Laboratory for Agrobiotechnology , Key Laboratory of ...