Zou Y, Su Z, Yang J, Zeng Y, Gu X: Uncovering genetic regulatory network divergence between duplicate genes using yeast eQTL landscape. Journal of Experimental Zoology Part B: Molecular and Developmental Evolution 2009, 312 (7) : 722-733. Publisher Full Text...
Blood eQTL Browser收集了来自七个中心的共5311名被试的血液组织中的基因型及基因表达量,进行(eQTL) meta分析,并在另外的四个中心的2775被试中重复验证,他们的研究与前两个数据库相比,发现了大量的trans-eQTL。 http://genenetwork.nl/bloodeqtlbrowser/ 3.又找到eQTL利用软件出结果的流程的推文,我就是资料整合专...
首先通过matrixEQTL软件进行eQTL分析,采用默认的距离阈值,SNP与gene的距离小于1Mb以内的为cis-eQTL, 大于1Mb的为trans-eQTL,识别到了1268个cis-eQTL, 10334个trans-eQTL, 通过之前介绍的cis-trans plot展示所有eQTL在染色体上的分布 上图中横坐标和纵坐标分别表示SNP和gene在染色体上的位置,图中的散点表示eQTL-gene...
Topological units of environmental signal processing in the transcriptional regulatory network of Escherichia coli Proc. Nat. Acad. Sci., 102 (2005), pp. 7841-7846 CrossrefView in ScopusGoogle Scholar [28] M.V. Rockman, L. Kruglyak Genetics of global gene expression Nat. Rev. Genet., 7 (...
disease risk. In the latter case, a variety of approaches now leverage the association between genetic variants and gene expression changes, including colocalization analysis1,2,3,4,5,6,7, transcriptome-wide association studies (TWAS)8,9, and gene regulatory network inference10,11,12,13,14,15...
The goal of mapping expression quantitative trait loci (eQTLs) is to identify genomic regions regulating gene expression traits, which can be gathered through microarrays, RNA-Seq, or related methods. Because thousands of expression traits are analyzed..
The dissection of a gene regulatory network (GRN) that complements the genome-wide association study (GWAS) locus and the crosstalk underlying multiple agronomical traits remains a major challenge. In this study, we generate 558 transcriptional profiles of lint-bearing ovules at one day post-anthesis...
This is another interesting observation, as REI1 is a Ribi gene with no known regulatory role. In summary, we have looked at three eQTL hotspots belonging to the Ribi group of hotspots and have shown experimentally that candidate regulators in each eQTL hotspot affect the expression of the ...
unique genes. This integrative analysis identifies candidate causal variants and elucidates potential regulatory mechanisms for genes underlying schizophrenia, bipolar disorder and Alzheimer’s disease. Buy this article Purchase on SpringerLink Instant access to full article PDF...
The impact of genetic regulatory variation active in early pancreatic development on adult pancreatic disease and traits is not well understood. Here, we generate a panel of 107 fetal-like iPSC-derived pancreatic progenitor cells (iPSC-PPCs) from whole g