The STRIVE and ARISE trials excluded those who had no therapeutic response to more than two classes of migraine prevention treatments (defined as an adequate trial of at least 6 weeks at the recommended dose without any benefit in terms of frequency, duration, or severity of the attacks, accord...
Metabolism and Excretion: Degraded by enzymatic proteolysis into small peptides and amino acids. Half-life: 27 days TIME/ACTION PROFILE (plasma concentrations) ROUTEONSETPEAKDURATION IV rapid end of infusion unknown Contraindication/Precautions Contraindication/Precautions Contraindication/Precautions Contraindica...
The population of DELIVER comprised predominantly white and female participants, which may limit generalizability to the full migraine population. Because of the range of prior preventive treatment types and prescribing possibilities, dosage and duration of prior preventive medication were considered outside...
Migraine prophylactic therapy should be aimed at improving quality of life, decreasing abortive drug therapy usage, as well as complications, and reducing attack frequency, severity, and/or duration. There are generally considered to be three broad classes of medications currently endorsed for migraine...