EB病毒(Epstein-Barr virus,EBV)是一种存在感染性的人类疱疹病毒,与多种淋巴增殖性疾病、B/T/NK细胞淋巴瘤、鼻咽癌(NPC)和胃癌(GC)有关。EBV可在人类宿主中建立终身潜伏(life-long latency),并擅长逃避宿主的先天和适应性免疫反应。 1、EBV相关癌症,潜伏期...
Provided are T cell receptors that recognize or bind to Epstein-Barr virus (EBV) antigens, genetically engineered cells, and cell-based therapies.WU, HAIYANGZHOU, JIEDENG, DACHUANLI, SIZHAO, LIXIAZHANG, LUCHEN, RUIBRYSON, PAULMUDGAL, POORVA PRAKASH...
including lymphoproliferative disorders. The oncogenic potential of Epstein–Barr virus is related to its ability to infect and transform B lymphocytes into continuously proliferating lymphoblastoid cells. However, Epstein–Barr virus has also been implicated...
FULL PAPER British Journal of Cancer (2018) 118, 534–545 | doi: 10.1038/bjc.2017.475 Keywords: Epstein–Barr virus; T-cell receptor; latent membrane protein-1; adoptive cell transfer; cancer immunotherapy A novel Epstein–Barr virus-latent membrane protein-1-specific T-cell receptor for TCR ...
TCRγ rearrangement and Epstein- Barr virus are detected both in lymphadenopathy of adult-onset Still's disease and in accompanying peripheral T-cell lymphoma doi:10.1111/pin.12106Pathology InternationalKazuyo YasudaYasunori MatsukiShinichi KobariJunnichi MatsuzakiKimiya SatoKuniaki Nakanishi...
Cytokine-induced killer (CIK) cells represent a novel immunotherapy because they target both virus-infected and transformed cells by T-cell receptor (TCR)–restricted and natural killer (NK) cell–like mechanisms. CIK cells are expanded from peripheral blood, bone marrow or cord blood mononuclear ...
The Epstein-Barr virus latent membrane protein-1 (LMP-1) is an integral membrane protein with a molecular weight of approximately 63 kDa [5]. LMP-1 expression in nude mice results in B-cell lymphoma [6]. LMP-1 induces a signaling response in cells that mimics a constitutively active form...
Major players operating in the global Epstein-Barr virus infection treatment market are: Atara Biotherapeutics, Inc Bristol-Myers Squibb Company Lion TCR Vironika, LLC Read more information here: https://www.transparencymarketresearch.c...
The majority of post-transplant lymphoproliferative disorders in renal transplant patients are of the B-cell phenotype, while the T-cell phenotype is rare. We report a case of Epstein Barr Virus-positive, T-cell lymphoma in a renal transplant patient, pr
Systemic Epstein-Barr-virus-positive T cell lymphoproliferative disease of childhood is an extremely rare disorder, characterized by clonal proliferation of Epstein-Barr-virus-infected T cells with an activated cytotoxic phenotype. The disease is more frequent in Asia and South America, with only few ...