EBNA, EBV-nuclear antigen; EBV, Epstein-Barr virus; HEK, human embryonic kidney; IFN, type I interferon; IRF3, interferon regulatory factor 3; RIG-I, retinoic acid-inducible gene I; TBK1, TANK-binding kinase 1.
Epstein-Barr virus (EBV) is associated with many human neoplasms, including Burkitt's lymphoma (BL). Endemic BL in central Africa is more often EBV-associated than BL in the United States, where sero-conversion for EBV occurs somewhat later than in Africa. Therefore, the EBV associa...
EBV是一种人类疱疹病毒,感染后在宿主的整个生命周期内以潜伏形式持续存在于B淋巴细胞中。相比始终为EB病毒血清阴性的人,EB病毒血清阳性者发生MS的风险增加了32.4倍。 《科学》标题微软翻译:纵向分析显示,EB 病毒感染与多发性硬化患病高相关 Longitudinal analysis reveals high prevalence of Epstein-Barr virus ...
EBV, Epstein–Barr virus; EBNA, Epstein–Barr nuclear antigen; miRNAs,EBV-encoded microRNAs; BARTs, BamHI A-encoded transcripts; LMP, latent membrane proteins; IM, infectious mononucleosis; PTLD, post-transplant lymphoproliferative diseases; CAEBV, chronic active EBV infection. Under the inducement of...
Epstein–Barr virus (EBV) immortalizes human B-lymphocytes and is implicated in the pathogenesis of lymphoid and epithelial cell malignancies. The EBV nuclear antigen (EBNA)-1 induces the accumulation of reactive oxygen species (ROS), which enables B-cell immortalization but causes oxidative DNA dama...
Latent genes have been shown to have significant transformation ability in EBV infected B-cells [4]. The Epstein-Barr virus latent membrane protein-1 (LMP-1) is an integral membrane protein with a molecular weight of approximately 63 kDa [5]. LMP-1 expression in nude mice results in B-...
Epstein-Barr virus (EBV) is closely associated with the high incidence of nasopharyngeal carcinoma in worldwide. Vaccination is one strategy with the potential to prevent the occurrence of EBV-associated cancers, but a suitable vaccine is yet to be licensed. Much vaccine development research focuses...
Epstein-Barr virus diffuse large B-cell lymphoma latent membrane protein 2A nuclear factor-κB programmed cell death ligand 1 immune escape Introduction Epstein-Barr virus (EBV)–positive diffuse large B-cell lymphoma (DLBCL) is a highly aggressive malignancy with poor response to the treatment and...
Latent Epstein-Barr virus (EBV) infection is associated with several types of cancer. Several clinical studies have targeted EBV antigens as immune therapeutic targets with limited efficacy of EBV malignancies, suggesting that additional targets might be important. BamHI-A rightward frame 1 (BARF1)...
Measurement of neutralizing antibodies to Epstein–Barr virus (EBV) is important for evaluation of candidate vaccines. The current neutralization assay is based on antibody inhibition of EBV transformation of B cells and requires 6 weeks to perform. We developed a rapid, quantitative flow cytometry as...