HLAtransfectionEplet 52SK is unique in the HLA eplet registry as targeting the whole family of DQA1*01 alleles. It is proposed as an antibody-verified eplet but has not been validated enough to deserve this label. Especially, confusion can occur with reactivity targeting the 52PQ eplet ...
To assign eplets unambiguously, we utilized a cohort of 5193 individuals with high resolution allele-level HLA genotypes from the National Kidney Registry. Using repeated random sampling to simulate donor-recipient genotype pairings based on the ethnic composition of the historical US deceased donor ...
PREDICTABILITY OF EPLET MISMATCH TO ACUTE REJECTION IN LOW LEVEL HLA ANTIGEN MISMATCHED KIDNEY TRANSPLANTATION: VALIDATION ANALYSIS OF KOREAN ORGAN TRANSPLANTATION REGISTRY (KOTRY) DATAJong Cheol Jeong, Hyeong Eun Son, Yeon Ho Park, Inwhee Park, Jae Berm Park, Dong Wan Chae, Jaeseok Yang,...
EpletImmunodominanceImmunogenicityGraft failureWe assessed implications of various eplet-compatibility strategies to death-censored graft failure (DCGF), defined as return to dialysis or re-transplantation, in a base-case scenario from the Scientific Registry of Transplant Recipients. To inform personalized...
HLA-DQ plays an important role and many studies have identified structurally defined DQ epitopes specifically recognized by antibodies; they have been recorded in the International HLA Epitope Registry http://www.epregistry.com.br but the list is still incomplete.Duquesnoy, Rene J.Honger, GideonHo...
registry-based study of pediatric recipients of primary renal allografts in Victoria, Australia between 1990 and 2014 to determine the association between HLA EpMM and clinical outcomes including graft failure, re-transplantation and dnDSA formation.A total of 196 patients were included in the analysis...
We conducted a retrospective cohort study in first-time adult kidney transplant candidates (N=161,308) using data from the Scientific Registry of Transplant Recipients and the Centers for Medicare and...doi:10.1097/00007890-201407151-00801R. Sapir-Pichhadze...
Methods We studied a cohort of 118,313 American 0% PRA first kidney transplant recipients (2000 to 2015) from the Scientific Registry of Transplant Recipients. Imputed allele-level donor and recipient HLA-A, -B, -C, -DRB1 and -DQB1 genotypes were converted to the repertoire of EMM. We ...
HLA-DQ plays an important role and many studies have identified structurally defined DQ epitopes specifically recognized by antibodies; they have been recorded in the International HLA Epitope Registry http//www.epregistry.com.br but the list is still incomplete. Pregnancy offers an attractive model ...
Finally, the last method utilizes the HLA Epitope Registry, which proposes a list of “antibody-verified” eplets that may be associated with higher immunogenicity, in other words, those that will most likely lead to antibody formation [14]. Meanwhile, tacrolimus (TAC)-based immunosuppressive ...