Many epithelial tissues are characterized by the presence of basal cells which serve the dual roles of self-renewal and of progression through terminal differentiation, to a functional state. Such tissues, when grown in vitro as primary explants, exhibit a characteristic pattern of outgrowth and ...
H. et al. Human type 1 innate lymphoid cells accumulate in inflamed mucosal tissues. Nature Immunol. 14, 221–229 (2013). CAS Google Scholar Fuchs, A. et al. Intraepithelial type 1 innate lymphoid cells are a unique subset of IL-12- and IL-15-responsive IFN-γ-producing cells. ...
Indications of malignancy are based on features such as nuclear atypia, high mitotic rate and infiltrative growth into adjacent tissues. Currently, benign and malignant myoepitheliomas are differentiated by mitotic count, presence of invasive growth, cellular polymorphism, tumour necrosis, or their ...
1A) and localization in several epithelial tissues characterized by glandular or tubular structures (Fig. 1a–d). Invariably, IRSp53 localized to the luminal-facing side of the human epithelial cells in human (Fig. 1a, b), adult mice (Fig. 1c), and in the pronephric ducts of developing ...
In the normal breast myoepithelial cells (MEPs) are located between the luminal cells and the basement membrane. By their location they might act as a barrier to tumor invasion. In ductal carcinoma in situ (DCIS) the myoepithelial layer is still present; however, Allinen and coworkers [70]...
Epithelial cells are characterized by cell-cell interactions, with the formation of tight junctions, lateral, apical, and basal membranes, polarized distribution of cellular components, and lack of mobility, whereas mesenchymal cells have loose interaction with other cells, are not polarized, and can ...
We demonstrate that these specialized progenitor cells are characterized by high levels of antigen-presenting genes, can be isolated by high expression of MHC class I marker H2-K1, and account for in vitro and in vivo regenerative activity of the lineage-labeled airway epithelium and aid in ...
The number and quality of cells in the epithelial sample are most important for the successful initiation of the airway epithelial cell cultures. The highest initial number of primary HAE cells can be obtained from tissues obtained via resection, transplantation or autopsy. However, these procedures ...
diminished junctional tension but attributes those of UJT mainly to augmented cellular propulsion. Through the actions of UJT and pEMT working independently, sequentially, or interactively, those tissues that are subject to development, injury, or disease become endowed with rich mechanisms for cellular ...
Intact skin and mucosal barriers are crucial for the maintenance of tissue homeostasis as they protect host tissues from infections, environmental toxins, pollutants and allergens. A defective epithelial barrier has been demonstrated in allergic and autoimmune conditions such as asthma, atopic dermatitis,...