To evaluate the role of Spred2 in colonic inflammation and tissue repair, WT and Spred2 KO mice were given 2% DSS in drinking water ad libitum, followed by water. As shown in Fig. 3a, WT mice began to lose weight on day 4, continued to lose weight until day 7, and slowly ...
3c). The infiltration of Ly6G-positive cells, most likely neutrophils, was markedly lower in the colon of Spred2 KO mice (Fig. 3d). Thus, Spred2 KO mice are resistant to DSS-induced tissue injury and inflammation. Absence of Spred2 in non-hematopoietic cells attenuated DSS-induced colitis...
Obesity and related type 2 diabetes are increasing at epidemic proportions globally. It is now recognized that inflammatory responses mediated within the adipose tissue in obesity are central to the development of disease. Once initiated, chronic inflammation associated with obesity leads to the modulatio...
Identification of nestin-positive putative mammary stem cells in human breastmilk. Cell Tissue Res. 2007;329(1):129–36. https://doi.org/10.1007/s00441-007-0390-x. Article PubMed Google Scholar Fan Y, Chong YS, Choolani MA, Cregan MD, Chan JK. Unravelling the mystery of stem/...
At the time of malignant transformation of epithelial cells, the many components of the tumor microenvironment (TME), such as the tumor cells themselves, the stromal cells in surrounding tissue and the infiltrating leukocytes cells generate an intratumoral inflammatory state by the aberrant expression ...
Identification of IgA+ and IgG+ cell populations The small intestines were removed for histological examination as previously described [22]. Briefly, the tissue was prepared using the Sainte-Marie technique for paraffin inclusion, and the paraffin blocks were cut into 4-µm sections. The numbers...