We argue that kindling of epilepsy occurs due to the formation of a large number of excitatory synaptic connections through a Hebbian learning mechanism. Several experimentally observed phenomena, such as the initial rapid growth and eventual saturation of the amplitude and duration of the after...
Also known as Encephalotrigeminal Angiomatosis, this rare condition is due to a mutation of the GNAQ gene in both males and females. For more information, visit the Epilepsy Foundation online
Unverricht-Lundborg disease (EPM1) occurs due to homozygous expansion mutation in the CSTB (cystatin B) gene [3]. It presents in early adolescence with myoclonus and generalized tonic-clonic seizures [1,2]. The myoclonic jerks are worse upon awakening and can also be action-triggered or stimu...
Traumatic brain injury usually occurs due to a number of causes such as traffic accidents or work accidents. Within 1 to 2 days, brain damage can trigger inflammatory reactions, attack and damage nerve cells and leave permanent scarring in the brain. This leads to a change in the concentration...
Epilepsy occurs as a result of abnormal electrical activity originating in thebrain.Braincells communicate by sending electrical signals in an orderly pattern. In epilepsy, these electrical signals become abnormal, giving rise to an "electrical storm" that produces seizures. These storms may be within...
Stroke is the most common cause of acquired epilepsy. The pathogenesis of epilepsy after stroke has been studied in depth, with some mechanisms confirmed while others being new hypotheses that awaits confirmation. Currently, it is widely accepted that epilepsy occurs after stroke due to the imbalance...
The reason that Epilepsy has been misunderstood has been mainly due to research not being conducted until the middle of the nineteenth century. There are six main types of seizures and many treatments that can assist an epileptic patient. Many facts and myths exist about a person who has ...
HH occurs once in every 100,000 to 200,000 births in the hypothalamus, which is located in the back of the brain and regulates functions such as mood, memory, and hormone release. HH also causes gelastic seizures, drop attacks, memory problems, cognitive difficulties, and depression, as wel...
Due to its complex and multifaceted nature, developing effective treatments for epilepsy is still a major challenge. To deal with this complexity we introduce the concept of degeneracy to the field of epilepsy research: the ability of disparate elements to cause an analogous function or malfunction....
In the past forty years of research there have been over thirty drugs approved for the treatment of epilepsy none of which are cannabinoids. Indeed, there appears to have been a prejudice against cannabinoids, possibly due to the scheduled nature of these compounds and/or the fact that THC, ...