lamotrigine, topiramate, valproic acid, zonisamide) have multiple mechanisms of action, and some (eg, phenytoin, carbamazepine, ethosuximide) have only one known mechanism of action, anticonvulsant agents can be divided into large groups based on their ...
GABAkines — advances in the discovery, development, and commercialization of positive allosteric modulators of GABA(A) receptors. Pharmacol. Ther. 234, 108035 (2022). Article CAS PubMed Google Scholar Löscher, W. & Rogawski, M. A. How theories evolved concerning the mechanism of action ...
These extracts and phytochemicals could be used for the treatment of epilepsy in humans in the future; however, further research is needed to study the exact mechanism of action, toxicity, and dosage to reduce their side effects. In this narrative review, we comprehensi...
This study demonstrates reduced functional voltage-gated sodium channels in the most important type of inhibitory interneurons in APP transgenic mice and the brain of people with AD, and presents a potential mechanism of decreased inhibition without neuronal loss. Article CAS PubMed PubMed Central ...
Epilepsy is a recurring neurological disease caused by the abnormal electrical activity in the brain. This disease has caused about 50 new cases in 100,000 populations every year with the clinical manifestations of awareness loss, bruising, and mobility
The chief medical officer at Stoke Therapeutics provided commentary on the promising mechanism of action of STK-001, an antisense agent, in the treatment of Dravet syndrome. [WATCH TIME: 3 minutes] APOE4 Allele Carriers and Parkinson Disease Named Among Highest Risk Factors for Epilepsy in Patient...
Information includes generic name, brand name, year approved for use in the United States, FDA approved indications; advantages/disadvantages in clinical use; mechanism of action; need for monitoring of blood levels; side effects; use in pregnancy and breastfeeding and interactions with other medicat...
There are a plethora of medications currently approved for use in partial epilepsy. However, despite the large number of medications available, seizure control often remains elusive. A new medication with a unique mechanism of action has recently been approved for the adjunctive treatment of partial ...
The mechanism of action of DBS can be delineated by anatomic connections, that is, the thalamic nucleus acts as a central relay station to the limbic system, which is closely connected to the hippocampus and extensive areas in neocortex. Lesions of the mammillothalamic tract have an anticonvulsan...
Mechanism Behind Novel STK-001 as Disease-Modifying Treatment for Dravet Syndrome: Barry Ticho, MD, PhD Barry Ticho, MD, PhD December 10th 2024 The chief medical officer at Stoke Therapeutics provided commentary on the promising mechanism of action of STK-001, an antisense agent, in the treatmen...