Finally, it is important to understand that most patients rely on caregivers for assistance with activities in their daily lives. When developing a patient’s management plan, it is valuable to consider the caregivers as well. For example, I commonly work with adults who go into adult day prog...
The framework of degeneracy may help reconcile the ‘impaired inhibition’ with the ‘enhanced excitation’ hypotheses not only in TLE but also for example in Dravet syndrome. A Dravet-like epileptic phenotype can arise as a consequence of a Nav1.1 sodium channel deletion in GABAergic interneurons....
Devices range from implantable neurostimulators to non-invasive wearable monitors, each offering unique benefits and addressing different aspects of epilepsy management. This progress is not only improving the quality of life for many patients but also opening new avenues for research and treatment. Dem...
ursolic acid, and oleanolic acid, from another antiepileptic plan,Artemisia indica, acting on GABAAreceptors with anticonvulsant effects [77] (Fig.1). These substances have enhanced the response of GABAAreceptors to GABA in a concentration-dependent manner, operating as a positive modulator of α1β...
Loddenkemper likened a seizure action plan to a household fire emergency plan. “I hope we will never have a fire in our house, but my family have discussed what to do if it happens,” he said. “That is what seizure action plans and self-management curricula can provide for families: ...
et al. The role of polytherapy in the management of epilepsy: suggestions for rational antiepileptic drug selection. Expert Rev. Neurotherap. 20, 167–173 (2020). Article CAS Google Scholar Li, M. C. & Cook, M. J. Deep brain stimulation for drug-resistant epilepsy. Epilepsia 59, 273...
Epilepsy update: diagnosis, classification and management LaurenHarris,HeatherAngus-Leppan, inMedicine, 2023 Level 2 – epilepsy type The diagnosis is clinical, supported by EEG. Ingeneralized epilepsy, the patient typically has generalized spike–wave activity on EEG. Infocal epilepsy,epileptiform disch...
The best management of multimorbid PWE requires a paradigm shift from the traditional single disease-single comorbidity approach and refocus on a person-centred approach. Improvements in health care must be informed by assessing the burden of multimorbidity associated with epilepsy, delineating disease cl...
aThis article through carding technology, technology management, enterprise management, the concept of project management, construction project technical management, explains the relationship between technical project management and project management and the important role of technical project management, and to...
particularly for extra-temporal epilepsy. Using PET with specific ligands could help us understand the pathophysiology of seizures, and improve the future management of epilepsy patients. Looking to the future, artificial intelligence and machine learning approaches hold promise for improving localisation an...