Traditionally, efforts to improve epilepsy surgery have aimed to better characterize the epileptogenic zone (EZ, defined as the minimal brain area or areas that need to be removed or disconnected to achieve seizure freedom9; by definition, this can only be confirmed after surgery, and prior to i...
Age of epilepsy onset as modulating factor for naming deficit after epilepsy surgery: a voxel-based lesion-symptom mapping study Caroline Reindl , Katrin Walther & Hajo M. Hamer Article 08 August 2023 | Open Access Automated analysis of a large-scale paediatric dataset illustrates the interde...
In some patients who have partial or complex partial seizures and don't respond to medical therapy, brain surgery may be an alternative treatment. The surgery involves removing a single small area of the brain tissue that is responsible for seizure activity. Alternatively, surgery may be done to...
Astrocyte-derived CCL2 participates in surgery-induced cognitive dysfunction and neuroinflammation via evoking microglia activation. Behavioural brain research, 2017, 332: 145-153. 37. Bianco F, Pravettoni E, Colombo A, et al. Astrocyte-derived ATP induces vesicle shedding and IL-1 beta release...
Understanding the impact of epilepsy surgery on the brain is crucial to improve surgical outcomes for patients. Here we provide a summary of studies imaging the postsurgical effects of epilepsy resection on the brain. We focus on MRI and PET studies of temporal lobe and pediatric epilepsy, ...
Non-resective surgical strategies provide an alternative for drug-resistant patients not amenable to resective surgery due to poorly localized seizure foci, multiple foci, or epileptogenic zones co-localizing with eloquent areas carrying high risks for a
Surgery Surgery may be a treatment option if a patient experiences a certain category of epilepsy, such as focal seizures, where seizures begin in a small, well-defined spot in the brain before spreading to the rest of the brain, according to theMayo Clinic. In these cases, surgery can hel...
Stereotactic viral delivery and surgery were based on the mouse brain atlas (Paxinos and Franklin, 2001). See the Supplement for details. 2.3. Hippocampal Kindling After ~ 7 days of recovery, we determined hippocampal afterdischarge thresholds (ADT), the minimal intensity that produced an after...
In some patients who have partial or complex partial seizures and don't respond to medical therapy, brain surgery may be an alternative treatment. The surgery involves removing a single small area of the brain tissue that is responsible for seizure activity. Alternatively, surgery may be done to...
A seizure may start in one part of your brain, or both sides may be affected. Depending on the type of seizure, you may have movements you cannot control, lose consciousness, or stare straight ahead. You may be confused or tired after the seizure. A seizure may last a few seconds or ...