Mammary development, Breast cancer, Stem cell, Differentiation, Epithelial, Epigenetics, Chromatin, Methylation, HistoneDifferentiation of stem cells into highly specialised cells requires gene expression changes brought about by remodelling of the chromatin architecture. During this lineage-commitment process,...
We then systematically characterized the dynamic functional landscapes of these REs by integrating multi-omics datasets, including gene expression, chromatin accessibility, and DNA methylation. We identified a core set (n = 6359) of ruminant-specific REs that are involved in liver development, ...
Understanding genetic and biological mechanisms underlying complex traits (e.g., causal variants and their corresponding tissues at specific physiological stages) is a main theme of research in the field of genetics and biology. In the past decade, genome-wide association studies (GWAS) have revealed...