Receptor, Epidermal Growth FactorAntineoplastic AgentsEnzyme InhibitorsAntibodies, MonoclonalProtein-Tyrosine KinasesClinical Trials as TopicSynonyms EGFR ; ERBB ; ErbB-1 ; HER1 ; PLG61 Definition The epidermal growth factor receptor (EGFR) is the prototype cell surface receptor for the epidermal growth ...
Epidermal Growth Factor Receptors EGFRis atransmembrane proteinthat is activated by specific ligands such asepidermal growth factor, transforming growth factor-α,amphiregulin, andbetacellulin. It is part of the ErbB family of receptors. It is also known as ErbB1 and Her1. Upon binding with growt...
Clinical implications of the expression of epidermal growth factor receptors in human transitional cell carcinoma To evaluate the distribution and density of epidermal growth factor (EGF) receptors (EGF-Rs) on urothelium, immunohistological studies using a monoclonal a... EM Messing - 《Cancer Resear...
Epidermal Growth Factor Receptor Inhibitors The presence of mutated epidermal growth factor receptors (EGFRs) in various cancer types has been associated with increased cellular proliferation. There are multiple subtypes of EGFR, one of which, HER2, will be discussed separately. Currently, EGFR inhibit...
EGFR位于细胞膜表面,靠与配体结合来激活信号转导,其配体包括转化生长因子(TGF-α,transforming growth factor-α)、双调蛋白(AR)、表皮生长因子(EGF,epidermal growth factor)、表皮调节素(EREG,epiregulin)以及β细胞素(BTC,beta cellulin)。当这些配体与EGFR结合后,能够诱导EGFR由单体转化为二聚体,同时EGFR还可能和...
and together with their receptors are expressed in granulosa cells65,66. Each growth factor increased phosphorylation of ERK in the granulosa cells, indicating that receptor signaling had been activated (Supplementary Fig.2c). Despite this, none of the growth factors triggered TZP retraction even aft...
Epidermal growth factor (EGF) receptors on primary-cultured human thyroid cells from 27 neoplasias (nine adenomas and 18 differentiated carcinomas) were analyzed and compared with those on the cultured nonneoplastic part of human thyroid cells. Total binding of 125I-EGF to the nonneoplastic part,...
Epidermal growth factor receptors were present on TE-671 cells, all four ependymomas, and two of the four glioblastomas multiforme. The number of EGFR's per cell for ependymomas were estimated to range from 1000 to 6000. Transferrin receptors were detected on TE-671 cells, two of the four...
Ligand-induced down-regulation of two growth factor receptors, EGF receptor (ErbB-1) and ErbB-3, correlates with differential ability to recruit c-Cbl, who... G Levkowitz,H Waterman,E Zamir,... - 《Genes Dev》 被引量: 1767发表: 1998年 A mutant epidermal growth factor receptor common in...
The epidermal growth factor (EGF) receptor family, also called the "ErbB-receptor family", consists of 4 receptor family members ErbB1 ( EGFR ), ErbB2 (Neu, HER2 ), ErbB3 ( HER3 ) and ErbB4 (HER4). ErbB-receptors can form heterodimers and mediate the actions of a variety of ...